Development of a Triazine-Based tert-Butylating Reagent, TriAT-tBu
Development of a Triazine-Based tert-Butylating Reagent, TriAT-tBu
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DOI：
10.1002/ejoc.201600663
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发表时间：
2016-08-01
影响因子：
2.8
通讯作者：
Kunishima, Munetaka
中科院分区：
文献类型：
--
作者：
Yamada, Kohei;Hayakawa, Naoko;Kunishima, Munetaka
摘要研制了一种新型叔丁基化试剂2,4,6-三（叔丁基）-1,3,5-三嗪（TriAT-tBu），用于醇和羧酸的酸催化叔丁基化反应。各种醇类和羧酸的反应与TriAT-tBu在催化量的酸的存在提供了相应的叔丁基醚和酯高收益良好。TriAT-tBu是一种空气稳定的固体，产率高，由廉价的原料合成，即三聚氰尿酸，丁氢钠和氢化钠。
A new tert-butylating reagent, 2,4,6-tris(tert-butoxy)-1,3,5-triazine (TriAT-tBu) has been developed for the acid-catalyzed tert-butylation of alcohols and carboxylic acids. The reaction of various alcohols and carboxylic acids with TriAT-tBu in the presence of a catalytic amount of an acid provided the corresponding tert-butyl ethers and esters in good to high yields. TriAT-tBu is an air-stable solid synthesized in good yield from inexpensive starting materials, namely, cyanuric chloride, tBuOH, and sodium hydride.