The role of serotonin in irritable bowel syndrome: implications for management.
The role of serotonin in irritable bowel syndrome: implications for management.
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DOI：
10.1007/s11894-008-0070-3
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发表时间：
2008-08-01
影响因子：
--
通讯作者：
Wiley, John W
中科院分区：
文献类型：
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作者：
Garvin, Brian;Wiley, John W
肠易激综合征（IBS）是一种鲜为人知的常见慢性疾病，其特征是在没有结构或生化异常的情况下，腹部不适与排便习惯改变有关。尽管与肠易激综合征相关的重大经济和个人负担，但治疗选择仍然有限。血清素被认为是肠道分泌、感觉和运动功能的关键神经递质。虽然肠易激综合征的病理生理机制尚不完全清楚，但有证据表明脑-肠信号和血清素代谢异常在其中发挥了作用。5 -羟色胺是一种被更好地理解的神经递质，它在人体中枢和肠道生理中的作用，在肠易激综合征中起作用。讨论了血清素信号，重点是受体亚型和靶向这些受体的治疗剂。有证据表明肠易激综合征与信号通路中不同步骤的血清素代谢紊乱有关，同时也指出了将血清素代谢改变作为肠易激综合征患者症状的唯一解释的局限性。
Irritable bowel syndrome (IBS) is a poorly understood, common, chronic condition characterized by -abdominal discomfort associated with altered bowel habits in the absence of structural or biochemical abnormalities. Despite the significant economic and personal burden associated with IBS, treatment options remain limited. Serotonin is recognized as a key neurotransmitter in intestinal secretory, sensory, and motor function. Although the pathophysiology of IBS is incompletely understood, there is evidence that abnormalities in brain-gut signaling and serotonin metabolism play a role. This article reviews the evidence that serotonin, one of the better-understood neurotransmitters with respect to its role in human central and intestinal physiology, plays a role in IBS. Serotonin signaling is discussed, with a focus on receptor subtypes and the therapeutic agents that target these receptors. Evidence that IBS is associated with perturbations in serotonin metabolism at various steps in the signaling pathway is also addressed, along with the limitations on alteration in serotonin metabolism as the sole explanation for the constellation of symptoms observed in patients with IBS.