Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism.
Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism.
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DOI：
10.1016/j.redox.2014.08.002
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发表时间：
2014
期刊：
影响因子：
11.4
通讯作者：
Fath, Melissa A.
中科院分区：
文献类型：
--
作者：
Allen, Bryan G.;Bhatia, Sudershan K.;Anderson, Carryn M.;Eichenberger-Gilmore, Julie M.;Sibenaller, Zita A.;Mapuskar, Kranti A.;Schoenfeld, Joshua D.;Buatti, John M.;Spitz, Douglas R.;Fath, Melissa A.
相对于正常细胞，癌细胞表现出代谢的显著改变，这些改变被认为会导致细胞来源的活性氧（ROS）（如O2·−和H2O2）的稳态水平增加。也有人提出癌细胞增加葡萄糖和氢过氧化物代谢以补偿ROS水平的增加。考虑到这一理论构建，合理的建议是，通过喂养高脂肪和低葡萄糖和其他碳水化合物的生酮饮食来迫使癌细胞使用线粒体氧化代谢，将选择性地引起癌症与正常细胞的代谢氧化应激。癌细胞中代谢氧化应激的增加反过来将被预测为选择性地使癌细胞对常规放射和化学疗法敏感。本文综述了支持生酮饮食可安全地用作常规放疗和化疗的辅助治疗这一假设的证据，并讨论了生酮饮食可增强癌细胞治疗反应的拟议机制。
Cancer cells, relative to normal cells, demonstrate significant alterations in metabolism that are proposed to result in increased steady-state levels of mitochondrial-derived reactive oxygen species (ROS) such as O2•−and H2O2. It has also been proposed that cancer cells increase glucose and hydroperoxide metabolism to compensate for increased levels of ROS. Given this theoretical construct, it is reasonable to propose that forcing cancer cells to use mitochondrial oxidative metabolism by feeding ketogenic diets that are high in fats and low in glucose and other carbohydrates, would selectively cause metabolic oxidative stress in cancer versus normal cells. Increased metabolic oxidative stress in cancer cells would in turn be predicted to selectively sensitize cancer cells to conventional radiation and chemotherapies. This review summarizes the evidence supporting the hypothesis that ketogenic diets may be safely used as an adjuvant therapy to conventional radiation and chemotherapies and discusses the proposed mechanisms by which ketogenic diets may enhance cancer cell therapeutic responses.
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影响因子：
2
作者：
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通讯作者：
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