Conflicts with transcription make early replication late.
Conflicts with transcription make early replication late.
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DOI：
10.1016/j.molcel.2022.08.026
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发表时间：
2022-09
期刊：
影响因子：
16
通讯作者：
E. Petermann
中科院分区：
文献类型：
--
作者：
E. Petermann
通过对缺乏同源重组的细胞中有丝分裂DNA合成位点进行测序，Groelly，Bhowmick及其同事展示了早期S期转录和复制之间的冲突如何导致复制不足的DNA持续到有丝分裂。
By sequencing sites of mitotic DNA synthesis in cells lacking homologous recombination, Groelly, Bhowmick, and colleagues show how conflicts between transcription and replication in early S phase can cause under-replicated DNA to persist into mitosis.