Rational design of capillary-driven flows for paper-based microfluidics
Rational design of capillary-driven flows for paper-based microfluidics
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DOI：
10.1039/c4lc01487a
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发表时间：
2015-01-01
期刊：
影响因子：
6.1
通讯作者：
Berli, Claudio L. A.
中科院分区：
文献类型：
--
作者：
Elizalde, Emanuel;Urteaga, Raul;Berli, Claudio L. A.
集成无源泵送的纸质检测试剂盒的设计需要对流体输送进行精确编程，必须在基底的几何形状中进行编码。这一要求在多步工艺中变得至关重要，其中流体处理必须准确且可重现。本工作从理论上研究了纸状基材中的毛细吸胀，以更好地理解流体输运的宏观几何形状的流动域。一个流体动力学模型推导出均匀的多孔基板与任意的横截面形状，它允许一个确定的横截面轮廓所需的规定的流体速度或质量传输速率。扩展的模型狭缝微通道也证明。在我们的实验室制造的原型的实验验证计算。所提出的方法构成了一个有价值的工具，纸为基础的检测的合理设计。
The design of paper-based assays that integrate passive pumping requires a precise programming of the fluid transport, which has to be encoded in the geometrical shape of the substrate. This requirement becomes critical in multiple-step processes, where fluid handling must be accurate and reproducible for each operation. The present work theoretically investigates the capillary imbibition in paper-like substrates to better understand fluid transport in terms of the macroscopic geometry of the flow domain. A fluid dynamic model was derived for homogeneous porous substrates with arbitrary cross-sectional shapes, which allows one to determine the cross-sectional profile required for a prescribed fluid velocity or mass transport rate. An extension of the model to slit microchannels is also demonstrated. Calculations were validated by experiments with prototypes fabricated in our lab. The proposed method constitutes a valuable tool for the rational design of paper-based assays.