Integrated pharmacokinetic-Pharmacodynamic (PK/PD) model to evaluate the in vivo antimicrobial activity of Marbofloxacin against Pasteurella multocida in piglets.
Integrated pharmacokinetic-Pharmacodynamic (PK/PD) model to evaluate the in vivo antimicrobial activity of Marbofloxacin against Pasteurella multocida in piglets.
复制标题
综合药代动力学-药效学 (PK/PD) 模型评价马保沙星对仔猪体内多杀性巴氏杆菌的抗菌活性
DOI：
10.1186/s12917-017-1099-z
复制
发表时间：
2017-06-15
影响因子：
2.6
通讯作者：
Zeng ZL
中科院分区：
文献类型：
--
作者：
Zeng QL;Mei X;Su J;Li XH;Xiong WG;Lu Y;Zeng ZL
Marbofloxacin 是一种兽用氟喹诺酮类药物，对多杀性巴氏杆菌具有高活性。我们根据猪体内时间杀灭数据，使用组织笼模型评估了它对多杀性疟原虫的体内活性。在用 B 型多杀性巴氏杆菌、血清型 2 攻击后，肌肉注射一系列 0.15 至 2.5 mg/kg 的剂量。24 小时浓度-时间曲线下面积除以最低抑菌浓度 (AUC24TCF/MIC) 的比值是与马波沙星体内抗菌效果相关的最佳 PK/PD 指数 (R2 = 0.9279)。通过抑制性 S 形 Emax 模型计算，实现 1-log10 CFU/ml 降低和 3-log10 CFU/ml（最大响应的 90%）降低所需的 AUC24TCF/MIC 分别为 13.48 小时和 57.70 小时。马波沙星足以治疗感染多杀性巴氏杆菌的猪。组织笼模型在实现这些 PK/PD 结果中发挥了重要作用。
Marbofloxacin is a veterinary fluoroquinolone with high activity against Pasteurella multocida. We evaluated it’s in vivo activity against P. multocida based on in vivo time-kill data in swine using a tissue-cage model. A series of dosages ranging from 0.15 to 2.5 mg/kg were administered intramuscularly after challenge with P. multocida type B, serotype 2. The ratio of the 24 h area under the concentration-time curve divided by the minimum inhibitory concentration (AUC24TCF/MIC) was the best PK/PD index correlated with the in vivo antibacterial effectiveness of marbofloxacin (R2 = 0.9279). The AUC24TCF/MIC necessary to achieve a 1-log10 CFU/ml reduction and a 3-log10 CFU/ml (90% of the maximum response) reduction as calculated by an inhibitory sigmoid Emax model were 13.48 h and 57.70 h, respectively. Marbofloxacin is adequate for the treatment of swine infected with P. multocida. The tissue-cage model played a significant role in achieving these PK/PD results.