An interdisciplinary research model to investigate psychosocial cofactors in disease: Application to HIV-1 pathogenesis.
An interdisciplinary research model to investigate psychosocial cofactors in disease: Application to HIV-1 pathogenesis.
复制标题
研究疾病中社会心理辅助因素的跨学科研究模型：在 HIV-1 发病机制中的应用。
DOI：
10.1016/s0889-1591(02)00069-7
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Kemeny,MargaretE
中科院分区：
文献类型：
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作者：
Kemeny,MargaretE
本文主张在流行病学、人类实验室研究、动物研究、体外研究和其他机制研究和干预研究的基础上，对心理社会危险因素和疾病的研究进行更广泛的跨学科概念化。提出了一个模型，该模型包括分离所提出的心理或社会贡献因素中的有效成分，并确定它们的神经基础、周围神经生理和病理生理学相关性以及临床疾病结果。对HIV-1致病机制的研究提供了这类研究的例子。艾滋病毒部分重点研究了应激生活经历的具体认知表征，作为塑造事件情感和神经生理影响的积极成分。这些认知状态和HIV进展之间的联系，以及这些关系的潜在神经生理学、病毒学和免疫学媒介被描述。对心理社会因素与癌症的研究提出了该模型的含义和扩展。
This paper argues for a broader interdisciplinary conceptualization of research on psychosocial risk factors and disease that relies on epidemiology, human laboratory-based studies, animal studies, in vitro and other mechanistic studies and intervention research. A model is proposed that includes the isolation of the active ingredients in the proposed psychological or social contributing factor, and a determination of their neural substrates, peripheral neurophysiological and pathophysiological correlates, and clinical disease outcomes. Research in HIV-1 pathogenesis provides examples of these kinds of studies. The HIV section highlights research that focuses on specific cognitive representations of stressful life experiences as active ingredients that shape the affective and neurophysiological impact of events. Links between these cognitive states and HIV progression, as well as the potential neurophysiologic, virologic, and immunologic mediators of these relationships are described. Implications and extensions of this model are derived for research on psychosocial factors and cancer.