A dynamic model of keratinocyte stem cell renewal and differentiation:: Role of the p21 WAF1/Cip1 and notch1 signaling pathways
A dynamic model of keratinocyte stem cell renewal and differentiation:: Role of the p21 WAF1/Cip1 and notch1 signaling pathways
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DOI：
10.1111/j.1087-0024.2004.09308.x
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发表时间：
2004-09-01
影响因子：
--
通讯作者：
Dotto, GP
中科院分区：
文献类型：
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作者：
Okuyama, R;LeFort, K;Dotto, GP
我们在这里提出了一个动态模型，在角化细胞干细胞，转运扩增群体和细胞之间的功能平衡是可逆的和不可逆的致力于分化。根据该模型，角质形成细胞干细胞群的大小可以在多个水平上控制，包括导致最终分化的事件序列中的相对较晚的步骤，以及受到异质细胞外环境的影响。我们讨论了在我们的实验室中，细胞周期蛋白/CDK抑制剂p21（WAF1/CiP1）和Notch1信号通路之间的互连如何为干细胞与固定和/或分化角质细胞群体的动态模型提供强有力的支持。
We present here a dynamic model of functional equilibrium between keratinocyte stem cells, transit amplifying populations and cells that are reversibly versus irreversibly committed to differentiation. According to this model, the size of keratinocyte stem cell populations can be controlled at multiple levels, including relative late steps in the sequence of events leading to terminal differentiation and by the influences of a heterogeneous extra-cellular environment. We discuss how work in our laboratory, on the interconnection between the cyclin/CDK inhibitor p21(WAF1/CiP1) and the Notch1 signaling pathways, provides strong support to this dynamic model of stem cell versus committed and/or differentiated keratinocyte populations.