Biological role of cell-free nucleic acids in cancer: the theory of genometastasis.
Biological role of cell-free nucleic acids in cancer: the theory of genometastasis.
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DOI：
10.1615/critrevoncog.v18.i1-2.90
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发表时间：
2013
影响因子：
--
通讯作者：
D. García-Olmo;D. García-Olmo
中科院分区：
文献类型：
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作者：
D. García-Olmo;D. García-Olmo
无细胞核酸（cfNA）在血浆中循环的现象为许多疾病（特别是癌症）的病理生物学的研究开辟了新的研究领域。这种cfNA的检测、定量和定性分析对于许多种类的癌症的诊断和管理具有越来越大的兴趣和效用，至少作为补充工具。cfNA的起源尚未确定，尽管可能有不止一个。对含有cfNA的微粒和微泡的研究肯定会对这个问题有更多的了解。在本文中，我们反思了其中的一些问题，并回顾了支持基因转移理论的证据，该理论认为cfNA在宿主细胞的肿瘤发生的肿瘤进展中具有生物学作用。
The phenomenon of cell-free nucleic acids (cfNA) circulating in plasma has opened new areas of research for the study of the pathobiology of many diseases, particularly cancer. The detection, quantitation and qualitative analysis of such cfNA have had an increasing interest and utility for diagnosis and management of many kinds of cancer, at least as complementary tools. The origin of cfNA is not yet established, although it is probable that there are more than one. The study of microparticles and microvesicles containing cfNA surely will shed more light on this issue. In the present article, we reflect on some of these issues and review the evidence that supports the Theory of Genometastasis, which attributes a biologic role of cfNA in tumor progression by oncogenesis of host cells.