Spontaneous development of multiple glandular and extraglandular lesions in aged IQI/Jic mice: a model for primary Sjogren's syndrome.

Spontaneous development of multiple glandular and extraglandular lesions in aged IQI/Jic mice: a model for primary Sjogren's syndrome.
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DOI：
10.1093/rheumatology/keh209
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发表时间：
2004-07
期刊：
Rheumatology
影响因子：
5.5
通讯作者：
K. Takada;M. Takiguchi;A. Konno;M. Inaba
K. Takada;M. Takiguchi;A. Konno;M. Inaba
中科院分区：
医学1区
文献类型：
--
作者：
K. Takada;M. Takiguchi;A. Konno;M. Inaba

文献摘要

相似文献

目的 在原发性干燥综合征（SS）中，除了泪腺和唾液腺的主要靶组织外，全身外分泌和非外分泌器官也经常受到影响。本研究旨在检查 IQI/Jic 小鼠（一种已记录有自身免疫性泪腺炎和唾液腺炎的 SS 动物模型）是否会像原发性 SS 一样在多个器官中出现炎症病变。方法对不同年龄的IQI/Jic小鼠进行系统组织病理学分析。使用免疫组织化学技术测定浸润淋巴细胞的表型。结果老年时不仅泪腺、唾液腺出现炎症病变，肺、胰腺、肾等多个器官也出现炎症病变，主要由CD4(+)T细胞和B细胞组成。所有这些器官中炎症病变的发生率和严重程度随着年龄的增长而增加。病变的组织学外观和扩散与人类原发性 SS 相似。结论 IQI/Jic 小鼠在多个外分泌和非外分泌器官中自发产生炎症细胞浸润。这一特征将 IQI/Jic 小鼠与其他小鼠模型区分开来，使它们有利于研究原发性 SS 全身受累的发病机制。
OBJECTIVE In primary Sjögren's syndrome (SS), systemic exocrine and non-exocrine organs are frequently affected, in addition to the major target tissues of the lacrimal and salivary glands. This study aimed to examine whether the IQI/Jic mouse, an animal model of SS whose autoimmune dacryoadenitis and sialoadenitis have been documented, develops inflammatory lesions in multiple organs as in primary SS. METHODS Systemic histopathological analysis was performed on IQI/Jic mice at various ages. Phenotypes of infiltrated lymphocytes were determined using immunohistochemical techniques. RESULTS Inflammatory lesions were observed not only in the lacrimal and salivary glands, but also in multiple organs, including the lung, pancreas and kidney at advanced ages, and were mainly composed of CD4(+) T cells and B cells. The incidence and severity of the inflammatory lesions increased with age in all these organs. The histological appearance and spreading of lesions were similar to those in human primary SS. CONCLUSIONS IQI/Jic mice spontaneously develop inflammatory cellular infiltrates in multiple exocrine and non-exocrine organs. This characteristic distinguishes IQI/Jic mice from other murine models, making them favourable for studies on the pathogenesis of systemic involvement in primary SS.