Noninvasive mapping of regional response to segmental allergen challenge using magnetic resonance imaging and [F-18]fluorodeoxyglucose positron emission tomography
Noninvasive mapping of regional response to segmental allergen challenge using magnetic resonance imaging and [F-18]fluorodeoxyglucose positron emission tomography
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DOI：
10.1002/mrm.20504
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发表时间：
2005-06-01
影响因子：
3.3
通讯作者：
Fain, SB
中科院分区：
文献类型：
--
作者：
Holmes, JH;Sorkness, RL;Fain, SB
磁共振（MR）和正电子发射断层扫描（PET）成像技术被结合起来，以证明肺部的局部通气和炎症，从而对与过敏性炎症相关的局部肺功能进行体内、无创评估。使用呼吸门控 He-3 磁共振成像 (MRI) 来可视化通气，使用 T-1 加权质子 MRI 来描绘炎症浸润，并使用 [F-18] 氟脱氧葡萄糖-PET 来检测炎症细胞的局部葡萄糖代谢，对四只棕色挪威大鼠进行节段性过敏原攻击前后的成像。进行分段过敏原激发，并对激发前和激发后的肺以及对侧肺进行比较。成像结果的共同配准表明，正如组织学所证实的，通气缺陷、炎症浸润和葡萄糖代谢增加的区域与过敏原攻击传递和炎症细胞募集的部位密切相关。该方法表明，功能性和解剖性 PET 以及 MRI 图像数据的融合可能有助于阐明肺部炎症过程的功能相关性。 (c) 2005 年 Wiley-Liss, Inc.
Magnetic resonance (MR) and positron emission tomography (PET) imaging techniques were coregistered to demonstrate regional ventilation and inflammation in the lung for in vivo, noninvasive evaluation of regional lung function associated with allergic inflammation. Four Brown Norway rats were imaged pre- and post segmental allergen challenge using respiratory-gated He-3 magnetic resonance imaging (MRI) to visualize ventilation, T-1-weighted proton MRI to depict inflammatory infiltrate, and [F-18]fluorodeoxyglucose-PET to detect regional glucose metabolism by inflammatory cells. Segmental allergen challenges were delivered and the pre- and postchallenge lung as well as the contralateral lung were compared. Coregistration of the imaging results demonstrated that regions of ventilation defects, inflammatory infiltrate, and increased glucose metabolism correlated well with the site of allergen challenge delivery and inflammatory cell recruitment, as confirmed by histology. This method demonstrates that fusion of functional and anatomic PET and MRI image data may be useful to elucidate the functional correlates of inflammatory processes in the lungs. (c) 2005 Wiley-Liss, Inc.