DUCHENNE MUSCULAR DYSTROPHY - FUNCTIONAL ISCHEMIA REPRODUCES ITS CHARACTERISTIC LESIONS
DUCHENNE MUSCULAR DYSTROPHY - FUNCTIONAL ISCHEMIA REPRODUCES ITS CHARACTERISTIC LESIONS
复制标题
DOI：
10.1126/science.172.3988.1143
复制
发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
DERRER, EC
中科院分区：
文献类型：
--
作者：
MENDELL, JR;ENGEL, WK;DERRER, EC
杜氏营养不良的早期和中期组织学病变的高度特征性的实验再现在大鼠的血管异常，主动脉结扎，这不会影响肌内血管的结构，和体液的血管活性物质5-羟色胺的组合。结扎或单独注射5-羟色胺都不会引起肌纤维的变化。这一结果建立了一个类似的联合机制的非结构性缺血发病机制在杜氏营养不良的可能性。提出的发病机制是相反的，一般认为，原因是肌肉纤维代谢的内在异常。
The highly characteristic early and midstage histological lesions of Duchenne dystrophy were reproduced experimentally in the rat by the combination of a vascular abnormality, aortic ligation, which does not affect the structure of the intramuscular blood vessels, and the humoral vasoactive substance 5-hydroxytryptamine. Neither ligation nor injection of 5-hydroxytryptamine alone causes changes in the muscle fibers. This result establishes the possibility of a similar combined mechanism for a nonstructural ischemia pathogenesis in Duchenne dystrophy. The proposed pathogenesis is contrary to the generally held idea that the cause is an intrinsic abnormality of muscle fiber metabolism.