Positive feedback may cause the biphasic response observed in the chemoattractant-induced response of Dictyostelium cells
Positive feedback may cause the biphasic response observed in the chemoattractant-induced response of Dictyostelium cells
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DOI：
10.1016/j.sysconle.2005.08.009
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发表时间：
2006-04-01
影响因子：
2.6
通讯作者：
Iglesias, PA
中科院分区：
文献类型：
--
作者：
Yang, L;Iglesias, PA
受到化学引诱剂刺激后，盘基网柄菌细胞表现出快速反应。几种细胞内蛋白质的浓度迅速上升，在大约 5-10 秒内达到最高水平，然后恢复到刺激前的水平。这种反应在许多其他趋化细胞中也存在，是阶跃干扰排斥的一个例子，生物学家将这一过程称为完美适应。然而，与其他细胞不同的是，盘基网柄菌细胞在趋化剂诱导的反应中观察到的最初的第一个峰值随后是一个较慢、较小的阶段，在刺激后约 1-2 分钟达到峰值。直到最近，人们对这种双相反应的本质还知之甚少。此外，第二阶段的起源尚不清楚。在本文中，我们推测反应和刺激之间存在反馈路径。使用化学引诱剂诱导的细胞反应的数学模型以及控制工程的标准工具，我们表明正反馈可能会引发第二个峰值。 (c) 2005 Elsevier B.V. 保留所有权利。
After stimulation by chemoattractant, Dictyostelium cells exhibit a rapid response. The concentrations of several intracellular proteins rise rapidly reaching their maximum levels approximately 5-10 s, after which they return to prestimulus levels. This response, which is found in many other chemotaxing cells, is an example of a step disturbance rejection, a process known to biologists as perfect adaptation. Unlike other cells, however, the initial first peak observed in the chemoattractant-induced response of Dictyostelium cells is then followed by a slower, smaller phase peaking approximately 1-2 min after the stimulus. Until recently, the nature of this biphasic response has been poorly understood. Moreover, the origin for the second phase is unknown. In this paper we conjecture the existence of a feedback path between the response and stimulus. Using a mathematical model of the chemoattractant-induced response in cells, and standard tools from control engineering, we show that positive feedback may elicit this second peak. (c) 2005 Elsevier B.V. All rights reserved.