CONTRIBUTION OF LEAD TO HYPERTENSION WITH RENAL IMPAIRMENT
CONTRIBUTION OF LEAD TO HYPERTENSION WITH RENAL IMPAIRMENT
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DOI：
10.1056/nejm198307073090104
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
WEDEEN, RP
中科院分区：
文献类型：
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作者：
BATUMAN, V;LANDY, E;WEDEEN, RP
原因不明的高血压通常被称为原发性高血压。由于高血压一直被认为是铅中毒的可能并发症和EDTA铅动员试验已被证明是一个敏感的指标，过量的身体储存的铅，这个测试被用来评估过去的累积铅吸收48名男性诊断为原发性高血压。患有高血压伴肾功能降低的患者（即，血清肌酸酐水平> 1.5 mg/ dl [133 μ mol/l]）的患者比患有高血压但无肾损害的患者具有显著更大的可活动Pb量。可移动的铅的增加是不是由于肾脏疾病本身，因为22例对照组患者没有原发性高血压的历史，但具有可比的肾功能损害，从已知的原因排泄显着减少铅螯合物在三天的测试。这些数据表明，铅可能有一个病因的作用，在肾脏疾病的一些患者通常指定为原发性高血压。
Hypertension of unknown cause is generally termed essential. Because hypertension has long been considered a possible complication of Pb poisoning and the EDTA Pb-mobilization test has proved to be a sensitive indicator of excessive body stores of Pb, this test was used to evaluate cumulative past Pb absorption in 48 men diagnosed as having essential hypertension. Patients who had hypertension with reduced renal function (i.e., serum creatinine level > 1.5 mg/ dl [133 .mu.mol/l]) had significantly larger amounts of mobilizable Pb than did patients who had hypertension without renal impairment. The increase in mobilizable Pb was not due to the renal disease itself, since 22 control patients without a history of essential hypertension but with comparable renal impairment from known causes excreted significantly less Pb chelate during the three-day test. These data suggest that Pb may have an etiologic role in the renal disease of some patients usually designated as having essential hypertension.