Heritability of macular thickness determined by optical coherence tomography
Heritability of macular thickness determined by optical coherence tomography
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DOI：
10.1167/iovs.05-0599
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发表时间：
2006-01-01
影响因子：
4.4
通讯作者：
Baird, PN
中科院分区：
文献类型：
--
作者：
Chamberlain, MD;Guymer, RH;Baird, PN
目的.研究遗传因素是否显著影响健康老年人黄斑厚度。一项经典的双胞胎研究进行了比较黄斑厚度之间的相关性单卵（MZ）和双卵（DZ）双胞胎在人口为基础的志愿者双胞胎的样本。该研究包括109对白色双胞胎，年龄从50岁到80岁，没有明显的眼病证据，矫正视力高于6/7.5。对所有受试者进行黄斑部光学相干断层扫描（OCT）、眼底照相、临床检查、眼部生物测量、健康饮食问卷和主观自动验光。在所有黄斑区域，MZ双生子之间的视网膜厚度相关性显著大于DZ双生子。黄斑中心凹区MZ与DZ的相关性为0.88：0.44，黄斑内区为0.79：0.47，黄斑外区为0.81：0.50。通过调整显著协变量和模型拟合，获得的最终遗传力估计值分别为85%、81%和81%。中心凹厚度与性别之间存在显著相关性，男性中心凹明显较厚。黄斑外厚度与眼轴长度呈显著负相关。这项研究证实，老年健康受试者的黄斑厚度（通过OCT测量）可能受到遗传因素的影响。眼轴长度、性别和年龄等因素作为可能影响黄斑厚度的变量，需要在更大规模的人群研究中进一步检查。这一发现表明黄斑厚度的遗传基础，并可能有助于了解控制黄斑结构和功能的因素。
PURPOSE. To examine whether genetic factors significantly influence macular thickness in healthy older subjects.METHODS. A classic twin study was performed to compare the correlation of macular thickness between monozygotic (MZ) and dizygotic (DZ) twins in a sample of population-based volunteer twins. The study included 109 white twin pairs from 50 to 80 years of age without evidence of manifest eye disease and corrected visual acuity better than 6/7.5. Dilated macular optical coherence tomography (OCT), fundus photography, clinical examination, ocular biometry, a health-dietary questionnaire, and subjective autorefraction were performed on all subjects.RESULTS. Correlation of retinal thickness was significantly greater between MZ twin pairs than DZ pairs in all macular regions. The MZ-to-DZ correlation was 0.88:0.44 for the foveal region, 0.79:0.47 for the inner macular region, and 0.81:0.50 for the outer macular region. With adjustment for significant covariates and model fitting, final heritability estimates of 85%, 81%, and 81%, respectively, were obtained. A significant correlation between foveal thickness and gender was present, with the men having significantly thicker foveae. There was a significant negative correlation between outer macular thickness and axial length.CONCLUSIONS. This study confirms that macular thickness in older healthy subjects, as measured by OCT, may be affected by genetic factors. Factors such as axial length, gender and age, warrant further examination in larger population-based studies, as variables that may influence macular thickness. This finding suggests an inherited basis of macular thickness and may help in the understanding of the factors that govern macular structure and function.