Acetaminophen Reduces Social Pain: Behavioral and Neural Evidence
Acetaminophen Reduces Social Pain: Behavioral and Neural Evidence
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DOI：
10.1177/0956797610374741
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发表时间：
2010-07-01
影响因子：
8.2
通讯作者：
Eisenberger, Naomi I.
中科院分区：
文献类型：
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作者：
DeWall, C. Nathan;MacDonald, Geoff;Eisenberger, Naomi I.
疼痛，无论是由身体伤害还是社会排斥引起，都是生活中不可避免的一部分。这两种类型的疼痛（身体疼痛和社交疼痛）可能依赖于一些相同的行为和神经机制来记录与疼痛相关的影响。在这些疼痛过程重叠的情况下，对乙酰氨基酚（一种通过中枢（而不是外周）神经机制发挥作用的物理疼痛抑制剂）也可能减少对社会排斥的行为和神经反应。在两项实验中，参与者每天服用对乙酰氨基酚或安慰剂，持续三周。对乙酰氨基酚的剂量可以减少日常社交疼痛的报告（实验 1）。我们使用功能性磁共振成像来测量参与者的大脑活动（实验2），发现对乙酰氨基酚减少了先前与社交疼痛和身体疼痛的情感成分引起的痛苦相关的大脑区域（背侧前扣带皮层、前岛叶）对社交排斥的神经反应。因此，对乙酰氨基酚减少了与社交排斥疼痛相关的行为和神经反应，表明社交疼痛和身体疼痛之间有很大的重叠。
Pain, whether caused by physical injury or social rejection, is an inevitable part of life. These two types of pain-physical and social-may rely on some of the same behavioral and neural mechanisms that register pain-related affect. To the extent that these pain processes overlap, acetaminophen, a physical pain suppressant that acts through central (rather than peripheral) neural mechanisms, may also reduce behavioral and neural responses to social rejection. In two experiments, participants took acetaminophen or placebo daily for 3 weeks. Doses of acetaminophen reduced reports of social pain on a daily basis (Experiment 1). We used functional magnetic resonance imaging to measure participants' brain activity (Experiment 2), and found that acetaminophen reduced neural responses to social rejection in brain regions previously associated with distress caused by social pain and the affective component of physical pain (dorsal anterior cingulate cortex, anterior insula). Thus, acetaminophen reduces behavioral and neural responses associated with the pain of social rejection, demonstrating substantial overlap between social and physical pain.