The characteristics of early-stage research into human genes are substantially different from subsequent research.
The characteristics of early-stage research into human genes are substantially different from subsequent research.
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DOI：
10.1371/journal.pbio.3001520
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发表时间：
2022-01
期刊：
影响因子：
9.8
通讯作者：
Nunes Amaral LA
中科院分区：
文献类型：
--
作者：
Stoeger T;Nunes Amaral LA
在过去的20年里，一些学者观察到，目前对人类基因的研究很少转向过去没有被广泛研究的基因。在科学和创新研究的假设指导下，我们在这里提出了一个文献范围内的数据驱动的元分析，以确定特定的科学和组织背景，在过去的半个世纪中，与人类基因的早期研究相吻合。我们证明，人类基因的早期研究在团队规模、引用影响、资助机制和出版渠道方面有所不同，但从科学和创新研究中得出的一般性见解仅部分适用于人类基因的早期研究。此外，我们表明，目前，基因组生物学占大多数的初始早期阶段的研究，而随后的早期阶段的研究可以从事其他生命科学领域。因此，我们预计，我们研究结果的特异性将使科学家和政策制定者能够更好地促进人类基因的早期研究，并增加生命科学领域的整体创新。一个文献范围内的数据驱动的元分析确定了特定的科学和组织背景下，恰逢早期阶段的研究人类基因在过去的半个世纪，揭示了从科学和创新的研究得出的一般性见解，只有部分适用于初步研究人类基因。
Throughout the last 2 decades, several scholars observed that present day research into human genes rarely turns toward genes that had not already been extensively investigated in the past. Guided by hypotheses derived from studies of science and innovation, we present here a literature-wide data-driven meta-analysis to identify the specific scientific and organizational contexts that coincided with early-stage research into human genes throughout the past half century. We demonstrate that early-stage research into human genes differs in team size, citation impact, funding mechanisms, and publication outlet, but that generalized insights derived from studies of science and innovation only partially apply to early-stage research into human genes. Further, we demonstrate that, presently, genome biology accounts for most of the initial early-stage research, while subsequent early-stage research can engage other life sciences fields. We therefore anticipate that the specificity of our findings will enable scientists and policymakers to better promote early-stage research into human genes and increase overall innovation within the life sciences. A literature-wide data-driven meta-analysis identifies the specific scientific and organizational contexts that coincided with early-stage research into human genes throughout the past half century, revealing that generalized insights derived from studies of science and innovation only partially apply to preliminary research into human genes.
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影响因子：
14.9
作者：
Buniello, Annalisa;MacArthur, Jacqueline A. L.;Parkinson, Helen
通讯作者：
Parkinson, Helen
影响因子：
5.8
作者：
Gillis, Jesse;Pavlidis, Paul
通讯作者：
Pavlidis, Paul
影响因子：
64.8
作者：
Dickinson ME;Flenniken AM;Ji X;Teboul L;Wong MD;White JK;Meehan TF;Weninger WJ;Westerberg H;Adissu H;Baker CN;Bower L;Brown JM;Caddle LB;Chiani F;Clary D;Cleak J;Daly MJ;Denegre JM;Doe B;Dolan ME;Edie SM;Fuchs H;Gailus-Durner V;Galli A;Gambadoro A;Gallegos J;Guo S;Horner NR;Hsu CW;Johnson SJ;Kalaga S;Keith LC;Lanoue L;Lawson TN;Lek M;Mark M;Marschall S;Mason J;McElwee ML;Newbigging S;Nutter LM;Peterson KA;Ramirez-Solis R;Rowland DJ;Ryder E;Samocha KE;Seavitt JR;Selloum M;Szoke-Kovacs Z;Tamura M;Trainor AG;Tudose I;Wakana S;Warren J;Wendling O;West DB;Wong L;Yoshiki A;International Mouse Phenotyping Consortium;Jackson Laboratory;Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS);Charles River Laboratories;MRC Harwell;Toronto Centre for Phenogenomics;Wellcome Trust Sanger Institute;RIKEN BioResource Center;MacArthur DG;Tocchini-Valentini GP;Gao X;Flicek P;Bradley A;Skarnes WC;Justice MJ;Parkinson HE;Moore M;Wells S;Braun RE;Svenson KL;de Angelis MH;Herault Y;Mohun T;Mallon AM;Henkelman RM;Brown SD;Adams DJ;Lloyd KC;McKerlie C;Beaudet AL;Bućan M;Murray SA
通讯作者：
Murray SA
影响因子：
3.5
作者：
Mihai IS;Das D;Maršalkaite G;Henriksson J
通讯作者：
Henriksson J
影响因子：
2.5
作者：
Germain, Pierre-Luc;Ratti, Emanuele;Boem, Federico
通讯作者：
Boem, Federico