Carcinoma of the duodenum.
Carcinoma of the duodenum.
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十二指肠癌。
DOI：
10.1136/gut.9.2.222
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发表时间：
1968
期刊：
影响因子：
24.5
通讯作者：
Colin E. Mackintosh
中科院分区：
文献类型：
--
作者：
Louis Kreel;Colin E. Mackintosh
Ewing（1931）指出，小肠恶性肿瘤的发病率为胃肠道肿瘤的3%。Shallow， Eger和Carty（1944）在350,286例尸检中报道原发性十二指肠癌的发生率为003%；45.6%的小肠肿瘤累及十二指肠。在这个系列中，我们小心地排除了壶腹、胆道和胰腺系统的未分化肿瘤，所有这些肿瘤都与十二指肠癌的发病率混合在一起。Ficarra和Marshall（1945）指出，如果包括壶腹区癌，按发生频率排序，十二指肠是小肠癌最常见的部位，因此必须特别注意病理，以确定原发部位并获得其发病率的真实数字。Spinazzola和Gillesby（1963）给出了十二指肠肿瘤在壶腹上区第一部分的分布为18-23%，第二部分为50-65%，第三部分为15-200%。他们回顾了1931年至1960年期间伊利诺斯州海恩斯退伍军人管理医院的肿瘤记录，发现了31例小肠肿瘤。其中390%（12例）发生在十二指肠，仅经鉴定的病例；12例中有8例为腺癌（3例类癌和1例平滑肌肉瘤）。大多数肿瘤为息肉样或溃疡型。男性的发病率约为女性的两倍，从症状出现到诊断的平均时间为6个月（Shallow, Eger, and Carty, 1945）至11个月（Dixon, Lichtman, and Weber, 1946）。这些肿瘤最常见于五、六十岁。
Ewing (1931) states that the incidence of malignant tumours of the small intestine is 3% of neoplasms of the gastrointestinal tract. Shallow, Eger, and Carty (1944) reported the incidence of primary carcinoma of the duodenum in a study of 350,286 necropsies as 003%; the duodenum is affected in 45.6% of cases of small intestinal neoplasms. In this series care was taken to exclude undifferentiated neoplasms of the ampulla of Vater and of the biliary and pancreatic systems, all of which are mixed with the figures for the incidence of duodenal carcinoma throughout its history. Ficarra and Marshall (1945) state that in order of frequency the duodenum is the commonest site for carcinoma of the small bowel if carcinoma of the ampullary region is included, and hence special attention must be paid to the pathology to establish the primary site and obtain true figures for its incidence. Spinazzola and Gillesby (1963) give the distribution of duodenal neoplasms for the first part of the supraampullary region as 18-23%, for the second part as 50-65%, and for the third part as 15-200%. In their review of the tumour registry at the Veterans Administration Hospital, Hines, Illinois, from 1931 to 1960 inclusive, they found 31 cases of small bowel neoplasm. Of these, 390% (12 cases) were in the duodenum and only authenticated cases were included; eight of the 12 were adenocarcinomas (three carcinoid and one leiomyosarcoma). Most of the tumours were of the polypoid or ulcerating type. The incidence in males is approximately twice that in females, the average time between the onset of symptoms and diagnosis six months (Shallow, Eger, and Carty, 1945) to 11 months (Dixon, Lichtman, and Weber, 1946). These neoplasms occur most frequently in the fifth and sixth decades.