Neuroticism Influences Brain Activity During the Experience of Visceral Pain
Neuroticism Influences Brain Activity During the Experience of Visceral Pain
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DOI：
10.1053/j.gastro.2011.06.008
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发表时间：
2011-09-01
期刊：
影响因子：
29.4
通讯作者：
Aziz, Qasim
中科院分区：
文献类型：
--
作者：
Coen, Steven J.;Kano, Michiko;Aziz, Qasim
背景与目的：已知影响疼痛体验的一个特别重要的个体动态是神经质，但在内脏疼痛研究中对其知之甚少。我们的目的是研究神经症、心理生理反应和大脑处理内脏疼痛之间的关系。方法：31名健康志愿者（男性15名，年龄22-38岁）参与研究。艾森克人格问卷用于评估神经质。在预期疼痛和疼痛性食管膨胀期间获得皮肤电导水平、疼痛等级和功能磁共振成像数据。采用相关分析评估神经质的影响。结果：神经质评分范围广泛（范围0-22），但神经质对皮肤电导水平和疼痛耐受性或疼痛评分没有影响。然而，在情绪和认知疼痛处理相关的区域，包括副海马体、脑岛、丘脑和前扣带皮层，发现了预期期间大脑活动与神经质之间的正相关。这些区域与疼痛时的神经质呈负相关（P < 0.001）。结论：这项研究提供了新的数据，表明高神经质与预期疼痛时负责情绪和认知评估的大脑区域的参与有关，但在疼痛时这些区域的活动减少。这可能反映了那些高度神经质的人的一种适应不良机制，即在预期时过度兴奋，在疼痛时回避应对。
BACKGROUND & AIMS: One particularly important individual dynamic known to influence the experience of pain is neuroticism, of which little is known about in visceral pain research. Our aim was to study the relationship between neuroticism, psychophysiologic response, and brain processing of visceral pain. METHODS: Thirty-one healthy volunteers (15 male; age range, 22-38 years) participated in the study. The Eysenck Personality Questionnaire was used to assess neuroticism. Skin conductance level, pain ratings, and functional magnetic resonance imaging data were acquired during anticipation of pain and painful esophageal distention. The effect of neuroticism was assessed using correlation analysis. RESULTS: There was a wide spread of neuroticism scores (range, 0-22) but no influence of neuroticism on skin conductance level and pain tolerance or pain ratings. However, a positive correlation between brain activity and neuroticism during anticipation was found in regions associated with emotional and cognitive pain processing, including the parahippocampus, insula, thalamus, and anterior cingulate cortex. These regions showed a negative correlation with neuroticism during pain (P < .001). CONCLUSIONS: This study provides novel data suggesting higher neuroticism is associated with engagement of brain regions responsible for emotional and cognitive appraisal during anticipation of pain but reduced activity in these regions during pain. This may reflect a maladaptive mechanism in those with higher neuroticism that promotes overarousal during anticipation and avoidance coping during pain.