ROS-induced ROS release in vascular biology: redox-redox signaling.
ROS-induced ROS release in vascular biology: redox-redox signaling.
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DOI：
10.1152/ajpheart.01271.2010
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发表时间：
2011-09
期刊：
影响因子：
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通讯作者：
N. Zinkevich;D. Gutterman
中科院分区：
文献类型：
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作者：
N. Zinkevich;D. Gutterman
活性氧自由基（ROS）参与调节正常血管中的血管功能以及作为疾病期间适应性反应的一部分已得到深入研究。从认识到ROS作为重要的信号分子，已经出现了多条证据，表明细胞内ROS产生位点之间存在功能性连接。这种串扰被称为ROS诱导的ROS释放（RIRR），并得到各种观察结果的支持，这些观察结果表明RIRR是ROS扩增和区域ROS产生的常见机制。细胞内ROS产生的区室化对其信号传导功能至关重要，并且通过特定清除剂的微定位来促进。本综述将提供RIRR重要机制的描述和实例。
The involvement of reactive oxygen species (ROS) in regulating vascular function both in normal vessels and as part of an adaptive response during disease has been intensively studied. From the recognition that ROS serve as important signaling molecules has emerged multiple lines of evidence that there is a functional connectivity between intracellular sites of ROS production. This cross talk has been termed ROS-induced ROS release (RIRR) and is supported by a variety of observations showing that RIRR is a common mechanism for ROS amplification and regional ROS generation. The compartmentalization of ROS production within a cell is critical to its signaling function and is facilitated by microlocalization of specific scavengers. This review will provide descriptions and examples of important mechanisms of RIRR.