Epidemiologic trends in head and neck cancer and aids in diagnosis.
Epidemiologic trends in head and neck cancer and aids in diagnosis.
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DOI：
10.1016/j.coms.2014.01.001
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发表时间：
2014-05
影响因子：
1.5
通讯作者：
Williams, Michelle D.
中科院分区：
文献类型：
--
作者：
Vigneswaran, Nadarajah;Williams, Michelle D.
头颈癌是全球第六大常见癌症，每年约有630，000名新诊断患者，导致每年超过350，000人死亡1。超过90%的头颈部癌症是鳞状细胞癌（HNSCC），其产生于口腔（OSCC，ICD-10代码：C 00 -08）、口咽（OPSCC，ICD-10代码：C 09 -10和C12-14）和喉（ICD-10代码C32-9）的粘膜表面。虽然在北方美洲和欧洲，HNSCC占所有新发癌症病例的5-10%，但全球HNSCC的发病率和解剖分布存在广泛的地理差异。这种变化主要归因于烟草使用和酒精消费习惯的人口统计学差异，这导致全球诊断的所有HNSCC中近80%的发展。在高风险国家（即印度，斯里兰卡，孟加拉国和巴基斯坦），口腔鳞状细胞癌是男性最常见的癌症，女性第三常见的癌症2。在欧洲国家中，法国的口腔鳞状细胞癌发病率最高，匈牙利、斯洛伐克和斯洛文尼亚的发病率也很高2。在美国（US），HNSCC仅构成男性中第八大最常见的癌症，每年约有53，600名患者被诊断，并且显示出相当低的死亡率，每年有11，500名患者死亡3。美国和其他发达国家口腔鳞状细胞癌和喉鳞状细胞癌发病率的下降与烟草制品使用的下降相吻合4。相比之下，最近口咽鳞状细胞癌（OPSCC）的发病率激增，这是由于该地区SCC的生物驱动因素发生变化，与人乳头状瘤病毒（HPV）高危亚型相关的频率越来越高。4，5。HPV相关© 2014 Elsevier Inc. All rights reserved.通讯作者：77054 713-486-4410电话：|传真：713-486-4416。vigneswaran@ uth. tmc。edu; www. DB. Uth。tmc。教育部电话：713-794-1765|，713-563-1848传真mdwillia@ mdanderson。org.
Head and neck cancers represent the sixth most common cancer worldwide with approximately 630,000 new patients diagnosed annually resulting in more than 350,000 deaths every year 1. More than 90% of head and neck cancers are squamous cell carcinomas (HNSCC) that arise from the mucosal surfaces of the oral cavity (OSCC, ICD-10 code: C00-08), oropharynx (OPSCC, ICD-10 code: C09-10 and C12-14) and larynx (ICD-10 code C32-9). While in Northern America and Europe, HNSCC accounts for 5-10% of all new cancer cases, there is wide geographical variation in the incidence and anatomic distribution of HNSCC worldwide. This variation is predominately attributed to demographic differences in the habits of tobacco use and alcohol consumption which contributes to the development of almost 80% of all HNSCC diagnosed globally. In high-risk countries (ie India, Sri Lanka, Bangladesh and Pakistan), OSCC is the most common cancer in men and the third most common cancer in women2. Among the European countries, the highest incidence of OSCC is in France with high rates also noted in Hungary, Slovakia and Slovenia2. In the United States (US), HNSCC constitutes only the eighth most common cancer among men with approximately 53,600 patients diagnosed yearly and shows a considerably lower mortality with 11,500 patient deaths annually3. The decreasing incidence of OSCC and laryngeal SCC in the US and in other developed countries coincides with decline in the use of tobacco products 4. By contrast, there is a recent upsurge in the incidence of oropharyngeal squamous cell carcinoma (OPSCC) which is attributed to a change in the biologic driver of SCC in this region with an increasing frequency of an association with high-risk subtypes of human papilloma virus (HPV) 4, 5. HPV associated© 2014 Elsevier Inc. All rights reserved. Corresponding Author: 77054 713-486-4410 tel| 713-486-4416 fax nadarajah. vigneswaran@ uth. tmc. edu; www. db. uth. tmc. edu 713-794-1765 tel|, 713-563-1848 fax mdwillia@ mdanderson. org.
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