Hippocampal Volume Is Reduced in Schizophrenia and Schizoaffective Disorder But Not in Psychotic Bipolar I Disorder Demonstrated by Both Manual Tracing and Automated Parcellation (FreeSurfer)
Hippocampal Volume Is Reduced in Schizophrenia and Schizoaffective Disorder But Not in Psychotic Bipolar I Disorder Demonstrated by Both Manual Tracing and Automated Parcellation (FreeSurfer)
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DOI：
10.1093/schbul/sbu009
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发表时间：
2015-01-01
影响因子：
6.6
通讯作者：
Tamminga, Carol A.
中科院分区：
文献类型：
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作者：
Arnold, Sara J. M.;Ivleva, Elena I.;Tamminga, Carol A.
本研究在中间表型双极-精神分裂症网络（B-SNIP）精神病样本中检查海马体积作为精神病疾病的推定生物标志物，对比手动追踪和半自动（FreeSurfer）感兴趣区域结果。研究样本（n = 596）包括精神分裂症（SZ，n = 71）、情感障碍（SAD，n = 70）和精神病性双相I型障碍（BDP，n = 86）先证者;他们的一级亲属（SZ-Rel，n = 74; SAD-Rel，n = 62; BDP-Rel，n = 88）;和健康对照（HC，n = 145）。海马体积是使用手动追踪/3DSlicer3.6.3和半自动化包裹/FreeSurfer5.1，64位从3 Tesla T1加权MP3图像中获得的。使用混合效应回归模型（SAS 9.3 Proc MIXED），在HC和先证者和亲属中比较了两种方法的体积结果;计算了手动追踪和FreeSurfer结果之间的Pearson相关性。与HC相比，SZ（P = .0007-.02）和SAD（P = .003-.14）的海马体积较低，而BDP显示双侧体积正常（P = .18-.55）。所有亲属组的海马体积与对照组无差异（P = 0.12 - 0.97），但高于先证者（P = 0.003 - 0.09），双极先证者与亲属的FreeSurfer测量除外（P = 0.64 - 0.99）。手动描记和FreeSurfer的结果显示出直接的、中度到强的相关性（r = 0.51 - 0.73，P <0.05）。这些来自大型精神病样本的发现支持海马体积减少作为精神分裂症和情感障碍的推定生物标志物，但不是精神病性双相I型障碍，并且可能反映了不同原发疾病过程和/或终生药物使用的累积效应。手动跟踪和半自动化分割区域体积的方法可以提供有用的结果，定义可测量的生物标志物的严重精神疾病。
This study examined hippocampal volume as a putative biomarker for psychotic illness in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) psychosis sample, contrasting manual tracing and semiautomated (FreeSurfer) region-of-interest outcomes. The study sample (n = 596) included probands with schizophrenia (SZ, n = 71), schizoaffective disorder (SAD, n = 70), and psychotic bipolar I disorder (BDP, n = 86); their first-degree relatives (SZ-Rel, n = 74; SAD-Rel, n = 62; BDP-Rel, n = 88); and healthy controls (HC, n = 145). Hippocampal volumes were derived from 3Tesla T1-weighted MPRAGE images using manual tracing/3DSlicer3.6.3 and semiautomated parcellation/FreeSurfer5.1,64bit. Volumetric outcomes from both methodologies were contrasted in HC and probands and relatives across the 3 diagnoses, using mixed-effect regression models (SAS9.3 Proc MIXED); Pearson correlations between manual tracing and FreeSurfer outcomes were computed. SZ (P = .0007-.02) and SAD (P = .003-.14) had lower hippocampal volumes compared with HC, whereas BDP showed normal volumes bilaterally (P = .18-.55). All relative groups had hippocampal volumes not different from controls (P = .12-.97) and higher than those observed in probands (P = .003-.09), except for FreeSurfer measures in bipolar probands vs relatives (P = .64-.99). Outcomes from manual tracing and FreeSurfer showed direct, moderate to strong, correlations (r = .51-.73, P < .05). These findings from a large psychosis sample support decreased hippocampal volume as a putative biomarker for schizophrenia and schizoaffective disorder, but not for psychotic bipolar I disorder, and may reflect a cumulative effect of divergent primary disease processes and/or lifetime medication use. Manual tracing and semiautomated parcellation regional volumetric approaches may provide useful outcomes for defining measurable biomarkers underlying severe mental illness.