Dosimetric comparison of left-sided whole breast irradiation with 3D-CRT, IP-IMRT and hybrid IMRT
Dosimetric comparison of left-sided whole breast irradiation with 3D-CRT, IP-IMRT and hybrid IMRT
复制标题
3D-CRT、IP-IMRT 和混合 IMRT 左侧全乳放疗的剂量学比较
DOI：
10.3892/or.2014.3058
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发表时间：
2014-05-01
期刊：
影响因子：
4.2
通讯作者：
Shen, Liangfang
中科院分区：
文献类型：
--
作者：
Xie, Xiaoxue;Ouyang, Shuyu;Shen, Liangfang
本研究的目的是比较三维适形放疗（3D-CRT）、四场逆计划调强放疗（IP-IMRT）和混合调强放疗技术（3D-CRT和IP-IMRT结合）在靶覆盖和危险器官照射方面的左全乳放射剂量学特征。对8例左侧保乳手术的3种方案进行了分析。根据计划靶体积（PTV）、剂量一致性、均匀性和剂量-体积直方图（DVHs）对正常组织的治疗体积进行比较。计算PTV、心脏、双侧肺、对侧乳房及乳腺周围软组织的dvh （VOB）体积。与传统的3D-CRT技术相比，IP-IMRT和混合IMRT技术可显著提高PTV剂量均匀性和符合性（CI）
The aim of this study was to compare the dosimetric characteristics of left-sided whole breast irradiation among 3-dimensional conformal radiotherapy (3D-CRT), 4-field inverse-planned intensity-modulated radiotherapy (IP-IMRT) and hybrid IMRT technique (combining 3D-CRT beams and IP-IMRT beams) with respect to target coverage and irradiation of organs at risk. The 3 different planning techniques were analyzed for 8 patients with left-sided breast conserving surgery. Plans were compared on the basis of planning target volume (PTV) dose conformity, homogeneity and the volumes of normal tissues treated based on dose-volume histograms (DVHs). DVHs were calculated for the PTV, heart, and the bilateral lungs, contralateral breast, and soft tissue surrounding the breast PTV (VOB) volume. IP-IMRT and hybrid IMRT techniques comparably improved the PTV dose homogeneity and conformity (CI) significantly, compared to the conventional 3D-CRT technique (P