Respiratory compensation point during incremental exercise as related to hypoxic ventilatory chemosensitivity and lactate increase in man
Respiratory compensation point during incremental exercise as related to hypoxic ventilatory chemosensitivity and lactate increase in man
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DOI：
10.2170/jjphysiol.50.449
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发表时间：
2000-08-01
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影响因子：
--
通讯作者：
Takano, N
中科院分区：
文献类型：
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作者：
Takano, N
在递增负荷运动中，肺通气-O-2摄取（（V）/点E-（V）/点O-2）关系有两个拐点：一个在较低（V）/点O-2处，称为呼吸阈值（VT）;另一个在较高（V）/点O-2处，称为呼吸补偿点（RCP）。研究了RCP的个体性与中枢和外周化学感受器的化学敏感性的关系，这些化学感受器分别通过静息时高碳酸血症缓解反应（HCVR）和低氧缓解反应（HVR）的估计以及运动期间乳酸增加的速率进行评估，它被估计为斜率差，（Δ斜率）在（V）对点O-2-（V）对点O-2关系的较低斜率（（V）对点CO2：CO2输出），并在VT和RCP之间的工作速率较高的斜率。22名男性和16名女性受试者进行了1 min递增负荷运动试验，直至力竭，其中VT，RCP和Delta斜率被确定。所有测量均针对体表面积进行归一化。在男性中，RCP的个体差异与HVR和Delta斜率的个体差异呈负相关（p
The pulmonary ventilation-O-2 uptake ((V) over dot E-(V) over dot O-2,) relationship during incremental exercise has two inflection points: one at a lower (V) over dot O-2, termed the ventilatory threshold (VT); and another at a higher (V) over dot O-2, the respiratory compensation point (RCP). The individuality of RCP was studied in relation to those of the chemosensitivities of the central and peripheral chemoreceptors, which were assessed by resting estimates of hypercapnic ventilatory response (HCVR) and hypoxic ventilatory response (HVR), respectively, and the rate of lactic acid increase during exercise, which was estimated as a slope difference (Delta slope) between a lower slope of (V) over dot O-2-(V) over dot O-2 relationship ((V) over dot CO2: CO2 output) obtained at work rates below VT and a higher slope at work rates between VT and RCP. Twenty-two male and sixteen female subjects underwent a 1 min incremental exercise test until exhaustion, in which VT, RCP and Delta slope were determined. All measures were normalized for body surface area. In the males, the individual difference in RCP was inversely correlated with those of HVR and Delta slope (p