Prognostic implication and immunological value of contactin 1 expression in pan-cancer
Prognostic implication and immunological value of contactin 1 expression in pan-cancer
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泛癌中接触蛋白1表达的预后意义和免疫学价值
DOI：
10.1002/ctd2.70
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发表时间：
2022-06-01
期刊：
影响因子：
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通讯作者：
Cui，Yuehong
中科院分区：
文献类型：
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作者：
Zhang，Lingyun;Zhang，Jiayu;Cui，Yuehong
CNTN 1与癌症进展和神经系统的发展有关。虽然越来越多的证据表明CNTN 1在许多研究领域中发挥着至关重要的作用，但仍然没有对CNTN 1和人类泛癌谱进行详细的系统分析。在这里，我们的目的是进行一个全面的调查CNTN 1属性跨泛癌症types.MethodsCNTN1 mRNA表达和基因组的变化进行了解剖GTEX，TCGA，和cBioPortal数据库。通过人多器官组织微阵列进行CNTN 1在人器官组织中的表达。此外，通过TCGA数据库进行CNTN 1与生存期、临床特征和免疫相关细胞浸润之间的相关性。结果在泛癌表达分析中发现CNTN 1表达异常，并能预测肿瘤的生存期。CNTN 1的主要变异类型为基因组突变。此外，发现CNTN 1的异常表达与泛癌中的MSI、MMR和TMB相关。通过ESTIMATE算法和TIMER数据库，CNTN 1与某些类型癌症中免疫相关细胞的浸润显著相关。特别是，癌症相关的成纤维细胞表明肿瘤免疫微环境的负调节。接下来，我们发现CNTN 1在人类泛癌中最常见的信号通路是来自GSEA分析的神经活性配体-受体相互作用。结论总之，这项研究突出了CNTN 1在人类泛癌中的预测功能，并为绘制CNTN 1在肿瘤发生和免疫调节中的景观提供了新的见解。
ObjectiveContactin 1 (CNTN1) is associated with developing the cancer progression and nervous system. Although increasing evidence suggests a crucial role for CNTN1 in many research areas, it is still no detailed systematic analysis of CNTN1 and the human pan‐cancer spectrum. Here, our purpose is to make a thorough investigation of CNTN1 properties across pan‐cancer types.MethodsCNTN1 mRNA expression and genomic alteration were dissected by GTEX, TCGA, and the cBioPortal database. CNTN1 expression in human organic tissues was performed via human multiple organ tissue microarrays. Furthermore, the correlations between CNTN1 and survival periods, clinical characteristics, and immune‐associated cells infiltration were performed through the TCGA database. Additionally, GSEA was carried out to delve into the biological actions of CNTN1 in pan‐cancer.ResultsWe discovered that CNTN1 expression was abnormal in pan‐cancer expression analysis and could predict the survival period of cancers. The primary alteration type of CNTN1 was a genomic mutation. In addition, the aberrant CNTN1 expression was found to be related to MSI, MMR, and TMB in pan‐cancer. CNTN1 was significantly related to the infiltration of immune‐associated cells in certain kinds of cancer through the ESTIMATE algorithm and TIMER database. In particular, the cancer‐associated fibroblasts indicate a negative regulation of the tumor immune microenvironment. Next, we found the most frequent signaling pathway of CNTN1 in human pan‐cancer was neuroactive ligand–receptor interaction from GSEA analysis.ConclusionIn conclusion, the investigation highlights the predictive function of CNTN1 in human pan‐cancer and affords novel insights for drawing a landscape of CNTN1 in tumorigenesis and immune regulation.