Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood
Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood
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DOI：
10.1016/j.neuroimage.2005.06.014
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发表时间：
2005-12-01
期刊：
影响因子：
5.7
通讯作者：
Lupien, S
中科院分区：
文献类型：
--
作者：
Pruessner, JC;Baldwin, MW;Lupien, S
自尊，即我们赋予自己的价值，与健康、预期寿命和生活满意度有关。与自尊相关的是内部控制点，即个体对控制自己结果的感知。最近，自尊和内部控制点的变化已被证明可以预测神经内分泌皮质醇对压力的反应。在一生中累积暴露于高水平的皮质醇与海马萎缩有关。因此，我们检查了海马体体积和皮质醇调节，以研究与自尊相关的潜在生物学机制。我们调查了16名健康青年（年龄范围2026岁）和23名健康老年人（年龄范围60-84岁）。年轻的受试者被暴露在社会心理压力任务中，而老年受试者则被评估他们的基础皮质醇调节。所有受试者均获得结构磁共振图像，并对内侧颞叶结构和全脑灰质进行体积分析。对老年人进行标准化的神经心理学评估，以评估认知能力水平，并排除神经退行性疾病的可能性。青年和老年受试者的自尊和内控制点与海马体积显著相关。在年轻人中，对社会心理压力任务的皮质醇反应与海马体积、自尊和控制点水平显著相关，而在老年人中，这些人格特质减缓了与年龄相关的认知衰退、皮质醇调节和整体脑容量下降模式。(c) 2005爱思唯尔公司版权所有。
Self-esteem, the value we place on ourselves, has been associated with effects on health, life expectancy, and life satisfaction. Correlated with self-esteem is internal locus of control, the individual's perception of being in control of his or her outcomes. Recently, variations in self-esteem and internal locus of control have been shown to predict the neuroendocrine cortisol response to stress. Cumulative exposure to high levels of cortisol over the lifetime is known to be related to hippocampal atrophy. We therefore examined hippocampal volume and cortisol regulation, to investigate potential biological mechanisms related to self-esteem. We investigated 16 healthy young (age range 2026 years of age) and 23 healthy elderly subjects (age range 60-84 years). The young subjects were exposed to a psychosocial stress task, while the elderly subjects were assessed for their basal cortisol regulation. Structural Magnetic Resonance Images were acquired from all subjects, and volumetric analyses were performed on medial temporal lobe structures, and whole brain gray matter. Standardized neuropsychological assessments in the elderly were performed to assess levels of cognitive performance, and to exclude the possibility of neurodegenerative disease. Self-esteem and internal locus of control were significantly correlated with hippocampal volume in both young and elderly subjects. In the young, the cortisol response to the psychosocial stress task was significantly correlated with both hippocampal volume and levels of self-esteem and locus of control, while in the elderly, these personality traits moderated age-related patterns of cognitive decline, cortisol regulation, and global brain volume decline. (c) 2005 Elsevier Inc. All rights reserved.