Biosensors for immune cell analysis-A perspective
Biosensors for immune cell analysis-A perspective
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DOI：
10.1063/1.4706845
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发表时间：
2012-06-01
期刊：
影响因子：
3.2
通讯作者：
Chang, H. -C.
中科院分区：
文献类型：
--
作者：
Revzin, Alexander;Maverakis, Emanual;Chang, H. -C.
用于疾病检测、药物筛选和抗体生产的单个免疫细胞或小免疫细胞集落的大规模并行分析代表了快速成熟的微制造和微流体技术的“杀手级应用”。在我们看来，未来的微制造固相和流式细胞仪平台将配备生物传感器和电/机械/光学致动器，并将实现细胞功能的多参数分析，分泌信号的实时检测以及被认为感兴趣的细胞的轻松检索。(C)2012年美国物理学会。[http：//dx.doi.org/10.1063/1.4706845]
Massively parallel analysis of single immune cells or small immune cell colonies for disease detection, drug screening, and antibody production represents a "killer app" for the rapidly maturing microfabrication and microfluidic technologies. In our view, microfabricated solid-phase and flow cytometry platforms of the future will be complete with biosensors and electrical/mechanical/optical actuators and will enable multi-parametric analysis of cell function, real-time detection of secreted signals, and facile retrieval of cells deemed interesting. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4706845]