Preeclampsia and genetic risk factors for thrombosis: A case-control study
Preeclampsia and genetic risk factors for thrombosis: A case-control study
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DOI：
10.1016/s0002-9378(99)70335-2
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发表时间：
1999-10-01
影响因子：
9.8
通讯作者：
Rosendaal, FR
中科院分区：
文献类型：
--
作者：
De Groot, CJM;Bloemenkamp, KWM;Rosendaal, FR
目的：最近，有人提出，遗传性凝血异常导致静脉血栓形成的风险增加可能在先兆子痫的发展中发挥作用。我们测试这一假设的妇女谁有先兆子痫与匹配的对照subjects.Study设计：我们进行了一项病例对照研究，163名妇女与先兆子痫在1991-1996年。对照组受试者的年龄和分娩日期相匹配。检测患者和对照组受试者是否存在凝血因子V Leiden、凝血酶原20210 A等位基因、蛋白C、蛋白S和抗凝血酶缺陷。结果：患者组和对照组的遗传危险因素患病率相似（12.9%，比值比为1.0，95%可信区间为0.5-3.9）。出乎意料的是，我们发现了一个高患病率的因子V莱顿在对照组（9.2%）。结论：我们发现没有差异的遗传危险因素血栓形成的患病率与先兆子痫的妇女与对照组相比。
OBJECTIVE: Recently, it has been proposed that hereditary coagulation abnormalities leading to an increased venous thrombosis risk may play a role in the development of preeclampsia. We tested this hypothesis in women who have had preeclampsia compared with matched control subjects.STUDY DESIGN: We conducted a case-control study of 163 women with preeclampsia during 1991-1996. Control subjects were matched for age and delivery date. Patients and control subjects were tested for the presence of factor V Leiden, prothrombin 20210A allele, protein C, protein S, and antithrombin deficiency. Logistic regression methods were used for data analysis.RESULTS: The prevalence of these genetic risk factors was similar in the patient group (12.9%) and the control group (12.9%; odds ratio, 1.0; 95% confidence interval, 0.5-3.9). Unexpectedly, we found a high prevalence of factor V Leiden in the control group (9.2%).CONCLUSION: We found no differences in the prevalence of genetic risk factors of thrombosis in women with preeclampsia compared with control subjects.