The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes.
The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes.
复制标题
6ckine在PLT小鼠中的表达降低是由于两个6ckine基因之一的缺失而导致的。
DOI：
10.1084/jem.190.8.1183
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发表时间：
1999-10-18
期刊：
影响因子：
--
通讯作者：
Lira SA
中科院分区：
文献类型：
--
作者：
Vassileva G;Soto H;Zlotnik A;Nakano H;Kakiuchi T;Hedrick JA;Lira SA
6 Ckine是一种不寻常的趋化因子，能够在体外吸引幼稚T淋巴细胞。最近有报道，淋巴器官中缺乏6Ckine表达是淋巴结T细胞（plt）突变缺乏纯合子小鼠的显著特征。这些小鼠在淋巴结、派伊尔集合淋巴结和脾的白色髓中显示出减少的T细胞数量。然而，plt小鼠中缺乏6Ckine表达的遗传原因仍然未知。在这里，我们证明，小鼠6Ckine是由两个基因编码，其中一个是在淋巴器官中表达，并删除plt小鼠。第二个6Ckine基因是完整的，并在plt小鼠中表达。
6Ckine is an unusual chemokine capable of attracting naive T lymphocytes in vitro. It has been recently reported that lack of 6Ckine expression in lymphoid organs is a prominent characteristic of mice homozygous for the paucity of lymph node T cell (plt) mutation. These mice show reduced numbers of T cells in lymph nodes, Peyer's patches, and the white pulp of the spleen. The genetic reason for the lack of 6Ckine expression in the plt mouse, however, has remained unknown. Here we demonstrate that mouse 6Ckine is encoded by two genes, one of which is expressed in lymphoid organs and is deleted in plt mice. A second 6Ckine gene is intact and expressed in the plt mouse.