Thin Calcium Phosphate Coatings for Medical Implants
Thin Calcium Phosphate Coatings for Medical Implants
复制标题
DOI：
10.1007/978-0-387-77718-4
复制
发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
K. Groot;J. Wolke;J. Jansen
中科院分区：
文献类型：
--
作者：
K. Groot;J. Wolke;J. Jansen
磷酸钙涂层（50 mm厚），特别是由等离子喷涂工艺制成的羟基磷灰石（HA）涂层，已成功用于骨科和牙科植入物，以改善这些植入物在骨中的固定。通过除等离子喷涂之外的各种技术形成的薄磷酸钙涂层（10mm厚）由于其改进的性能而可能是当前厚等离子喷涂涂层的后继者。与等离子喷涂HA涂层一样，这些替代性磷酸钙薄涂层能够在其表面上形成骨并与新形成的骨形成结合。此外，薄的磷酸钙涂层已经显示出更好的附着到基底上，并且在生物环境中更稳定，因为它们具有比等离子体喷涂的HA涂层更均匀的结构和组成。此外，这些薄磷酸钙涂层中的一些可以形成在包括聚合物的所有种类的基底上以及复杂几何形状的整个表面上，例如多孔表面。这本书提出，第一次，曾经分散的新颖的结果，已经取得了近年来在研究各种薄磷酸钙涂层生产的不同技术。薄的磷酸钙涂层与厚的等离子喷涂的比较。读者会发现一个全面的工作，审查该领域的艺术状态，与各种制备技术的成就的关键评估收集。重点放在这种类型的薄涂层，这可能是特别有用的研究生的特殊表征技术的好处。这些信息也被认为是非常有价值的工业应用。这一综合性的努力，总结了最先进的生物活性磷酸钙涂层和审查的物理化学性质和在体外和体内性能的薄磷酸钙涂层制备的各种技术。它不仅对研究生物材料的学生有价值，而且对设计，开发和制造医疗植入物的工程师也有价值。
Calcium phosphate coatings ($50 mm thick), especially those made with hydroxyapatite (HA), produced by the plasma-spraying process have been successfully used on orthopedic and dental implants to improve fixation of these implants in bone. Thin calcium phosphate coatings (10 mm thick) formed by various techniques other than plasma spraying may be the successor of the current thick plasma-sprayed coatings because of their improved properties. Like plasma-sprayed HA coatings, these alternative calcium phosphate thin coatings are capable of enabling bone formation on their surfaces and forming a bond with the newly formed bone. In addition, the thin calcium phosphate coatings have shown better adhesion to substrates and are more stable in the biological environment because they have more uniform structure and composition than plasma-sprayed HA coatings. Moreover, some of these thin calcium phosphate coatings can be formed on all kinds of substrates including polymers and on the entire surfaces of complex geometries such as porous surfaces. This book presents, for the first time, the once scattered novel results that have been achieved in recent years in studies on various thin calcium phosphate coatings produced by diverse techniques. Comparisons of thin calcium phosphate coatings with the thick plasma-sprayed ones are included. Readers will find a comprehensive collection of work that reviews the state of the art of the field, with critical assessments of the achievements of the various preparation techniques. Emphasis is placed on the benefits of special characterization techniques for this type of thin coating, which may be particularly useful to graduate students. The information is also considered extremely valuable for industrial applications.This comprehensive effort summarizes the state of the art in bioactive calcium phosphate coatings and reviews the physicochemical properties and in vitro and in vivo performance of thin calcium phosphate coatings prepared by various techniques. It can be valuable not only to students involved in studying biomaterials but also to engineers in the design, development, and manufacture of medical implants.