Multimodal Imaging in Choroideremia
Multimodal Imaging in Choroideremia
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DOI：
10.1007/978-3-030-27378-1_23
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Duncan, Jacque L.
中科院分区：
文献类型：
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作者：
Foote, Katharina G.;Roorda, Austin;Duncan, Jacque L.
无脉络膜症（CHM）与视网膜色素上皮（RPE）、脉络膜毛细血管（CC）和光感受器的进行性变性有关。由于缺乏CHM的动物模型，大多数关于细胞存活的信息来自受影响患者的成像。本章讨论了成像技术的组合，包括眼底引导微视野、共焦和非共焦自适应光学扫描激光检眼镜（AOSLO）、眼底自体荧光（FAF）和扫描源光学相干断层扫描血管造影（SS-OCTA），分别分析黄斑敏感性、视锥细胞外段和内段结构、RPE结构和CC灌注。本文所述的联合成像方式可以提供监测CHM患者视网膜结构和功能的敏感措施。
Choroideremia (CHM) is associated with progressive degeneration of the retinal pigment epithelium (RPE), choriocapillaris (CC), and photoreceptors. As animal models of CHM are lacking, most information about cell survival has come from imaging affected patients. This chapter discusses a combination of imaging techniques, including fundus-guided microperimetry, confocal and non-confocal adaptive optics scanning laser ophthalmoscopy (AOSLO), fundus autofluorescence (FAF), and swept-source optical coherence tomography angiography (SS-OCTA) to analyze macular sensitivity, cone photoreceptor outer and inner segment structure, RPE structure, and CC perfusion, respectively. Combined imaging modalities such as those described here can provide sensitive measures of monitoring retinal structure and function in patients with CHM.