T-helper 1-related chemokines in the exacerbation of childhood asthma
T-helper 1-related chemokines in the exacerbation of childhood asthma
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DOI：
10.1111/j.1442-200x.2007.02533.x
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发表时间：
2008-02-01
影响因子：
1.4
通讯作者：
Suen, Jau-Ling
中科院分区：
文献类型：
--
作者：
Lai, Shu-Tse;Hung, Chih-Hsing;Suen, Jau-Ling
背景：辅助性T细胞（Th）2细胞因子被认为介导了与特应性哮喘相关的大多数过敏性炎症反应。但Th1相关的趋化因子，干扰素诱导蛋白10（IP-10）/CXCL10，是人类过敏性肺晚期反应中测量的主要趋化因子。本研究旨在探讨Th1和Th2相关趋化因子在哮喘急性发作发病机制中的作用。方法：检测稳定期哮喘患者血浆中Th2相关C-C趋化因子I-309（CCL 1）、Th1相关CXC趋化因子IP-10和干扰素γ（Mig）/CXCL 9诱导的单核细胞因子水平。将这些结果与皮质类固醇治疗前和治疗后哮喘急性发作患者的测量结果进行比较。与哮喘稳定期患者相比，急性发作期患者的IP-10和Mig血浆水平显著升高，但I-309未升高。血浆IP-10和Mig的水平显着较高的患者在急性哮喘急性发作期间比在随后的恢复期。结论：Th1相关的CXC趋化因子IP-10和Mig可能是有用的炎症标志物的哮喘急性发作的儿童。
Background: T-helper (Th) 2 cytokines are thought to mediate most of the allergic inflammatory responses associated with atopic asthma. But the Th1-related chemokine, interferon-inducible protein 10 (IP-10)/CXCL10, was the predominant chemokine measured during human allergic pulmonary late-phase reaction. The aim of the present study was to evaluate the role of Th1- and Th2- related chemokines in the pathogenesis of asthma exacerbation.Methods: Plasma levels of the Th2-related C-C chemokine I-309 (CCL1), the Th1-related CXC chemokines IP-10, and the monokine induced by interferon-gamma (Mig)/CXCL9 were measured in patients with stable asthma.Result: These results were compared to the results measured prior to, and after corticosteroid treatment, in patients who experienced asthma exacerbations. A significant increase in the plasma levels of IP-10 and Mig, but not I-309, were found in patients with an acute exacerbation in contrast to patients with stable asthma. Plasma levels of IP-10 and Mig were significantly higher in patients during an acute asthma exacerbation than during a subsequent convalescent period.Conclusions: The Th1-related CXC chemokines IP-10 and Mig may be useful inflammatory markers of asthma exacerbation in children.