The impact of cancer pathology confirmation on clinical management of a family history of cancer
The impact of cancer pathology confirmation on clinical management of a family history of cancer
复制标题
DOI：
10.1007/s10689-010-9407-9
复制
发表时间：
2011-06-01
期刊：
影响因子：
2.2
通讯作者：
Lucassen, A.
中科院分区：
文献类型：
--
作者：
Edwards, E.;Lucassen, A.
英国的区域癌症遗传学服务机构将许多风险评估建立在对疾病家族史的仔细评估之上。亲属癌症的病理细节可以帮助完善这种风险评估并改变随后的管理。通过分析各种医疗记录，我们调查了报告的家族史与记录中记录的不一致的频率，以及这对监测建议的影响频率。我们的调查分析了在7个月的转诊期内的家庭病理学确认和风险评估。报告了839例癌症，476例被独立证实。报告的家族史的准确性取决于报告的癌症部位和与患者的关系程度。虽然大多数报告的癌症（84%）得到证实，但通过病理学确认的风险评估的变化导致20%的转诊患者改变了治疗。
Regional cancer genetics services in the UK base many of their risk assessments on the careful evaluation of a family history of disease. The pathological details of cancers in relatives can help refine this risk assessment and alter subsequent management. By analysing a variety of medical records, we surveyed how often a reported family history was discrepant from that recorded in the records, and how often this impacted on surveillance recommendations. Our survey analysed pathology confirmation and risk assessment in families over a 7-month period of referrals. 839 cancers were reported and 476 were independently confirmed. The accuracy of a reported family history differed depending on the reported site of a cancer and on the degree of relationship to the patient. Whilst the majority of reported cancers (84%) were confirmed, a change in risk assessment through pathology confirmation resulted in altered management in 20% of all referrals.