Effect of Zhuang Jing Decoction on Learning and Memory Ability in Aging Rats
Effect of Zhuang Jing Decoction on Learning and Memory Ability in Aging Rats
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DOI：
10.1089/rej.2015.1751
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发表时间：
2016-08-01
影响因子：
2.6
通讯作者：
Wang, Qi
中科院分区：
文献类型：
--
作者：
Cai, Hao-Bin;Wu, Guang-Liang;Wang, Qi
随着人类平均寿命的延长，老龄化问题在世界范围内引起了广泛关注。脑区单胺类神经递质和神经营养因子参与学习和记忆过程，是正常突触神经传递和可塑性的重要组成部分。本研究采用Morris水迷宫法观察庄经汤对衰老大鼠学习记忆能力的影响。采用高效液相色谱荧光检测器和酶联免疫吸附法分别检测脑内单胺类神经递质和神经营养因子水平。这些数据表明，口服30g.kg（-1）剂量的ZJD对衰老大鼠的学习记忆能力有改善作用。结果表明，ZJD能有效调节大鼠单胺类神经递质和神经营养因子，恢复脑内单胺类神经递质和神经营养因子水平的平衡，最终减轻学习记忆能力的退化。这些结果表明，ZJD可能是一种潜在的认知增强药物，可以改善学习和记忆能力。其作用机制可能是通过调节脑内单胺类神经递质和神经营养因子的水平来实现的，表明中药复方具有一定的抗衰老作用。
With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present study, the effect of Zhuang Jing Decoction (ZJD) on the learning and memory ability in aging rats was examined in vivo using Morris water maze. Furthermore, the levels of monoamine neurotransmitters and neurotrophic factors in brain were detected by high-performance liquid chromatography with a fluorescence detector and enzyme-linked immunosorbent assay, respectively. These data showed that oral administration with ZJD at the dose of 30g.kg(-1) exerted an improved effect on learning and memory ability in aging rats. The results revealed that ZJD could effectively adjust the monoamine neurotransmitters and neurotrophic factors, restore the balance of the level of monoamine neurotransmitters and neurotrophic factors in brain, and finally attenuate the degeneration of learning and memory ability. These findings suggested that ZJD might be a potential agent as cognitive-enhancing drug in improving learning and memory ability. It may exert through regulating the levels of monoamine neurotransmitters and neurotrophic factors in brain, which demonstrated that ZJD had certain antiaging effects.