Load-Adaptive Scaffold Architecturing: A Bioinspired Approach to the Design of Porous Additively Manufactured Scaffolds with Optimized Mechanical Properties
Load-Adaptive Scaffold Architecturing: A Bioinspired Approach to the Design of Porous Additively Manufactured Scaffolds with Optimized Mechanical Properties
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DOI：
10.1007/s10439-011-0465-4
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发表时间：
2011-11
影响因子：
3.8
通讯作者：
A. Rainer;S. Giannitelli;D. Accoto;S. De Porcellinis;E. Guglielmelli;M. Trombetta
中科院分区：
文献类型：
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作者：
A. Rainer;S. Giannitelli;D. Accoto;S. De Porcellinis;E. Guglielmelli;M. Trombetta
计算机辅助组织工程（CATE）是基于一套用于制造患者特定支架的增材制造技术，其几何形状从医学成像中获得。关于CATE应用的主要问题之一涉及制造支架的内部结构的定义，这反过来又影响它们的孔隙率和机械强度。本研究设想了一种创新的策略，高度优化的结构制造的基础上，thea优先有限元分析（FEA）的生理负荷设置在植入部位。由此产生的支架微结构不遵循规则的几何图案;相反，它是基于数值研究的结果。该算法被应用于固体自由形式的制造过程中，使用聚（ε-己内酯）作为增材制造结构的加工的起始材料。选择了一种简单直观的几何形状作为原理验证应用程序，并对其进行了有限元模拟和机械测试。然后，为了证明创建机械仿生结构的能力，考虑了承受生理载荷条件的股骨近端，并设计和制造了适合股骨头部分的结构。
Computer-Aided Tissue Engineering (CATE) is based on a set of additive manufacturing techniques for the fabrication of patient-specific scaffolds, with geometries obtained from medical imaging. One of the main issues regarding the application of CATE concerns the definition of the internal architecture of the fabricated scaffolds, which, in turn, influences their porosity and mechanical strength. The present study envisages an innovative strategy for the fabrication of highly optimized structures, based on thea priorifinite element analysis (FEA) of the physiological load set at the implant site. The resulting scaffold micro-architecture does not follow a regular geometrical pattern; on the contrary, it is based on the results of a numerical study. The algorithm was applied to a solid free-form fabrication process, using poly(ε-caprolactone) as the starting material for the processing of additive manufactured structures. A simple and intuitive geometry was chosen as a proof-of-principle application, on which finite element simulations and mechanical testing were performed. Then, to demonstrate the capability in creating mechanically biomimetic structures, the proximal femur subjected to physiological loading conditions was considered and a construct fitting a femur head portion was designed and manufactured.