Cancer risk in Swedish women:: the relation to size at birth
Cancer risk in Swedish women:: the relation to size at birth
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DOI：
10.1054/bjoc.2000.1738
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发表时间：
2001-05-04
影响因子：
8.8
通讯作者：
Hulthén, L
中科院分区：
文献类型：
--
作者：
Andersson, SW;Bengtsson, C;Hulthén, L
研究人员对 1080 名瑞典成年女性的胎儿生长（以出生时体重和身长表示）与癌症风险之间的关系进行了研究。从 1914 年、1918 年、1922 年和 1930 年的原始助产士记录中检索出生因素，并通过与 1998 年的国家和地区癌症登记处匹配来确定原发性癌症病例。随着所有部位癌症和非激素相关癌症（定义为除乳腺癌、子宫和卵巢之外的所有癌症部位）的出生体重或出生身长的增加，发现癌症风险呈正向且具有统计显着性增加。添加怀疑影响癌症风险的因素、母亲蛋白尿、出生顺序、自己的产次和初潮年龄，并没有减弱这种关系。此前，据报道，只有乳腺癌与成年女性的出生时体型有关，这是第一项研究报告，除主要激素相关部位之外的癌症部位可能会受到出生时体型的影响，通过出生时的体重或身长来衡量；这些发现值得进一步调查。 (C) 2001 年癌症研究运动。
The relationship between fetal growth as indicated by weight and length at birth, and cancer risk in 1080 adult Swedish women was examined. Birth factors were retrieved from original midwife records far the years 1914, 1918, 1922 and 1930, and primary cancer cases were identified by matching with national and regional cancer registries through the year 1998. A positive and statistically significant increased risk for cancer was found with increasing birth weight or birth length for all site cancer and non-hormone related cancer, defined as all cancer sites excluding breast, uterus and ovary. Addition of factors suspected to influence cancer risk, maternal proteinuria, birth order, own parity and age at menarche, did not attenuate this relation. Previously only breast cancer has been reported to be related to size at birth in adult women and this is the first study to report that cancer sites other than the major hormone-related sites may be influenced by size at birth, as measured by either weight or length at birth; these findings warrant further investigation. (C) 2001 Cancer Research Campaign.