Mapping of the human visual cortex using image-guided transcranial magnetic stimulation
Mapping of the human visual cortex using image-guided transcranial magnetic stimulation
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DOI：
10.1016/s1385-299x(02)00189-7
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发表时间：
2002-10-01
期刊：
影响因子：
--
通讯作者：
Pascual-Leone, A
中科院分区：
文献类型：
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作者：
Fernandez, E;Alfaro, A;Pascual-Leone, A
我们描述了一个协议，使用经颅磁刺激（TMS）系统地映射的视觉感觉引起的局部和非侵入性刺激人类枕叶皮层。使用8字形线圈将TMS应用于枕骨区域上方28个位置，这些位置以2x2 cm网格排列。一个数字化平板电脑连接到一台PC计算机运行定制的软件，音频和视频记录用于详细和准确的数据收集和分析诱发光幻视。无框架图像引导神经导航装置用于描述刺激线圈相对于皮质表面的实际位置。我们的研究结果表明，TMS是能够引起光幻视在几乎所有的有视力的科目和盲人科目的比例。诱发的光幻视是按地形学组织的。尽管个体间存在微小差异，但映射结果是可重复的，并且在不同受试者之间显示出良好的一致性。这一过程有可能提高我们对人类视觉系统的生理组织和可塑性变化的理解，并建立盲人视觉皮层剩余功能的程度。这种非侵入性的方法是至关重要的皮质视觉假体选择合适的主题。(C)2002 Elsevier Science B.V.保留所有权利。
We describe a protocol using transcranial magnetic stimulation (TMS) to systematically map the visual sensations induced by focal and non-invasive stimulation of the human occipital cortex. TMS is applied with a figure of eight coil to 28 positions arranged in a 2x2-cm grid over the occipital area. A digitizing tablet connected to a PC computer running customized software, and audio and video recording are used for detailed and accurate data collection and analysis of evoked phosphenes. A frameless image-guided neuronavigational device is used to describe the position of the actual sites of the stimulation coils relative to the cortical surface. Our results show that TMS is able to elicit phosphenes in almost all sighted subjects and in a proportion of blind subjects. Evoked phosphenes are topographically organized. Despite minor inter-individual variations, the mapping results are reproducible and show good congruence among different subjects. This procedure has potential to improve our understanding of physiologic organization and plastic changes in the human visual system and to establish the degree of remaining functional visual cortex in blind subjects. Such a non-invasive method is critical for selection of suitable subjects for a cortical visual prosthesis. (C) 2002 Elsevier Science B.V. All rights reserved.