Antibacterial Activity of Certain Ferns Against Multi Drug Resistant Organisms

Antibacterial Activity of Certain Ferns Against Multi Drug Resistant Organisms
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某些蕨类植物对多重耐药生物的抗菌活性

DOI：
10.18311/jnr/2017/15758
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
A. Bhattacharjee
A. Bhattacharjee
中科院分区：
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文献类型：
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作者：
K. Nath;A. Talukdar;M. Bhattacharya;Deeshikha Bhowmik;Shiela Chetri;D. Choudhury;A. Mitra;A. Bhattacharjee

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三种重要民族药用蕨类植物叶提取物的抗菌活性Angioopteris helferiana C. Presl、Cyathea brunoniana (Wall. ex Hook.) C.B. Clarke & Baker 和 Pronephrium nudatum (Roxb. ex Griff) Holttum 采用良好扩散法对多重耐药微生物（即大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌）进行了测定。结果显示，Cyathea brunoniana、Pronephriumnudatum 的乙酸乙酯叶提取物对耐甲氧西林金黄色葡萄球菌有活性，而 Angiopteris helferiana 的乙酸乙酯叶提取物仅对金黄色葡萄球菌 (ATCC 25923) 有活性。结果发现，桫椤、Pronephriumnudatum 的乙酸乙酯叶粗提取物对耐甲氧西林金黄色葡萄球菌的最低抑菌浓度为 400 mg/ml。粗提物与抗生素的协同活性表明，抗生素分别与桫椤粗提物和原肾粗提物协同作用，抗菌活性增强。因此，结果表明使用桫椤和Pronephriumnudatum的蕨类提取物作为未来治疗耐甲氧西林金黄色葡萄球菌的可能性。
Antibacterial activity of frond extracts of three ethno medicinal important ferns viz. Angiopteris helferiana C. Presl, Cyathea brunoniana (Wall. ex Hook.) C.B. Clarke & Baker and Pronephrium nudatum (Roxb. ex Griff) Holttum was assayed by well diffusion method against multi drug resistant organisms i.e., Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The result revealed that the ethyl acetate frond extract of Cyathea brunoniana, Pronephriumnudatum were active against methicillin resistant Staphylococcus aureus while that of Angiopteris helferiana was active against only Staphylococcus aureus (ATCC 25923). The minimum inhibitory concentration of crude ethyl acetate frond extract of Cyathea brunoniana, Pronephriumnudatum was found to be 400 mg/ml against methicillin resistant Staphylococcus aureus. The synergistic activity of the crude extract with the antibiotics showed that the antibacterial activity of the antibiotics increased in synergy with crude extract of Cyathea brunoniana and Pronephriumnudatum respectively. Thereby, the results indicated the possibility of using the fern extract of Cyathea brunoniana and Pronephriumnudatum as a future treatment option against methicillin resistant Staphylococcus aureus.