CORRELATION OF PLASMA-HORMONE LEVELS AND PERIPHERAL CIRCULATING LYMPHOCYTE SUBPOPULATIONS DURING HUMAN-PREGNANCY
CORRELATION OF PLASMA-HORMONE LEVELS AND PERIPHERAL CIRCULATING LYMPHOCYTE SUBPOPULATIONS DURING HUMAN-PREGNANCY
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DOI：
10.1016/0165-2478(84)90070-1
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发表时间：
1984-01-01
影响因子：
4.4
通讯作者：
BARDOS, P
中科院分区：
文献类型：
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作者：
CANEPA, S;HOROWITZ, R;BARDOS, P
应用单克隆抗体（OKT3、OKT4、OKT8）测定40例正常初产妇外周血淋巴细胞亚群，并与31例未孕对照进行比较。孕妇血浆中雌二醇、孕酮、人胎盘乳原（HPL）、人绒毛膜促性腺激素亚基（hcg）和α。用放射免疫法测定胎儿蛋白。研究外周血淋巴细胞亚群与血浆激素水平的相关性。在闭经10至40周的孕妇中，OKT3和OKT8细胞的百分比下降。在怀孕期间，OKT4细胞的百分比有所增加。这种增加与血浆β呈负相关。HCG水平与血浆HPL水平直接相关。
Using monoclonal antibodies (OKT3, OKT4, OKT8) peripheral blood lymphocyte subsets were determined in 40 normal primiparous pregnant women and compared with those of 31 nonpregnant controls. In pregnant women plasma concentrations of estradiol, progesterone, human placental lactogen (HPL), beta subunit of human chorionic gonadotropin (.beta.HCG) and .alpha.-fetoprotein were measured by means for radioimmunoassay. Correlations between peripheral lymphocyte subsets and plasma hormone levels were studied. In pregnant women from 10 to 40 wk of amenorrhea a decrease in the percentage of OKT3 and OKT8 cells was noted. An increase in the percentage of OKT4 cells was noted during the course of pregnancy. This increase inversely correlated with plasma .beta.HCG levels and directly correlated with plasma HPL levels.