Foundational dendritic processing that is independent of the cell type-specific structure in model primary neurons.
Foundational dendritic processing that is independent of the cell type-specific structure in model primary neurons.
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DOI：
10.1016/j.neulet.2015.10.017
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发表时间：
2015-11-16
影响因子：
2.5
通讯作者：
Heckman CJ
中科院分区：
文献类型：
--
作者：
Kim H;Heckman CJ
人们早就知道，大脑和脊髓中的初级神经元表现出非常独特的树突状结构。然而，目前还不清楚树突处理信号传播和通道激活树突是一个功能的细胞类型特异性树突结构。通过应用扩展的信号衰减的神经突触输入和树突分支上的活动通道的生理分布的分析，我们首先证明，无论其具体结构，所有解剖重建模型的初级神经元显示出类似的模式的定向信号衰减和定位通道激活在他们的树突。然后，使用一种新的建模方法，它允许直接比较的解剖重建的原代神经元与他们的简化模型，专门保留解剖树突信号，而不与结构特异性，我们表明，简化模型可以准确地预测树突兴奋性的解剖模型在被动和主动模式。这些结果表明，定向信号，位置兴奋性和它们之间的关系是树突加工的基本特征，是独立的细胞类型特异性结构的初级神经元。
It has long been known that primary neurons in the brain and spinal cord exhibit very distinctive dendritic structures. However, it remains unclear whether dendritic processing for signal propagation and channel activation over dendrites is a function of the cell type-specific dendritic structure. By applying an extended analysis of signal attenuation for the physiological distributions of synaptic inputs and active channels on dendritic branches, we first demonstrate that regardless of their specific structure, all anatomically reconstructed models of primary neurons display a similar pattern of directional signal attenuation and locational channel activation over their dendrites. Then, using a novel modeling approach that allows direct comparison of the anatomically reconstructed primary neurons with their reduced models that exclusively retain anatomical dendritic signaling without being associated with structural specificity, we show that the reduced model can accurately predict dendritic excitability of the anatomical model in both passive and active mode. These results indicate that the directional signaling, locational excitability and their relationship are foundational features of dendritic processing that are independent of the cell type-specific structure across primary neurons.