No evidence for genotoxicity in mice due to exposure to intermediate-frequency magnetic fields used for wireless power-transfer systems
No evidence for genotoxicity in mice due to exposure to intermediate-frequency magnetic fields used for wireless power-transfer systems
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DOI：
10.1016/j.mrgentox.2021.503310
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发表时间：
2021-01-29
影响因子：
1.9
通讯作者：
Hattori, Kenji
中科院分区：
文献类型：
--
作者：
Ohtani, Shin;Ushiyama, Akira;Hattori, Kenji
时变磁场（MF）用于无线功率传输（WPT）技术。特别是，85 kHz频带MF，其包括在中频（IF）频带（300 Hz？10 MHz），是电动汽车充电常用的WPT系统。WPT技术的这些应用引起了公众对IF-MF健康影响的关注。然而，现有的健康风险评估数据不足，需要更多的数据。我们评估了IF-MF暴露对小鼠红系分化的遗传毒性作用。构建了高强度IF-MF小鼠暴露系统，以诱导54.1 V/m的平均全身电场。在2周IF-MF暴露（1小时/天，总计：10小时）之前和之后从雄性小鼠获得血液样品; X射线照射的小鼠用作阳性对照。我们用微核试验和Pig-a突变试验分析了血液样品。在IF-MF暴露和假暴露的小鼠之间，在成熟红细胞和网织红细胞中MN或Pig-a突变的频率中没有观察到显著差异。在研究条件下，IF-MF暴露未诱导体内遗传毒性（2.36？国际非电离辐射防护委员会（ICNIRP）指南中职业照射的基本限制为22.9 V/m）。由于IF-MF暴露而没有显著的生物学效应，支持该技术的实际应用。
Time varying magnetic fields (MFs) are used for the wireless power-transfer (WPT) technology. Especially, 85 kHz band MFs, which are included in the intermediate frequency (IF) band (300 Hz ? 10 MHz), are commonly used WPT system for charging electric vehicles. Those applications of WPT technology have elicited public concern about health effects of IF-MF. However, existing data from health risk assessments are insufficient and additional data are needed. We assessed the genotoxic effects of IF-MF exposure on erythroid differentiation in mice. A high-intensity IF-MF mouse exposure system was constructed to induce an average whole-body electric field of 54.1 V/m. Blood samples were obtained from male mice before and after a 2-week IF-MF exposure (1 h/ day, total: 10 h); X-irradiated mice were used as positive controls. We analyzed the blood samples with the micronucleus (MN) test and the Pig-a mutation assay. No significant differences were seen between IF-MFexposed and sham-exposed mice in the frequencies of either MN or Pig-a mutations in mature erythrocytes and reticulocytes. IF-MF exposure did not induce genotoxicity in vivo under the study conditions (2.36? the basic restriction for occupational exposure, 22.9 V/m, in the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines). The absence of significant biological effects due to IF-MF exposure supports the practical application of this technology.