Influence of Heavy Cigarette Smoking on Heart Rate Variability and Heart Rate Turbulence Parameters
Influence of Heavy Cigarette Smoking on Heart Rate Variability and Heart Rate Turbulence Parameters
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DOI：
10.1111/j.1542-474x.2009.00321.x
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发表时间：
2009-10-01
影响因子：
1.9
通讯作者：
Akdemir, Ramazan
中科院分区：
文献类型：
--
作者：
Cagirci, Goksel;Cay, Serkan;Akdemir, Ramazan
方法：重度吸烟定义为每天吸烟超过20支。本研究招募了69名重度吸烟者和74名不吸烟者（对照组）。根据24小时霍尔特记录评估HRV和HRT分析[湍流起始（TO）和湍流斜率（TS）]。重度吸烟组TO值显著高于对照组（分别为-1.150 +/- 4.007 vs -2.454 +/- 2.796，P = 0.025），但两组TS值无统计学差异（分别为10.352 ± 7.670和9.613 ± 7.245，P = 0.555）。重度吸烟组TO异常者23例，对照组10例，差异有统计学意义（P = 0.006）。TO与每日吸烟量相关（r = 0.235，P = 0.004）。而LF和LF/HF比值显着较高，所有NN间期的标准差（SDNN），5分钟平均RR间期的标准差（SDANN），连续差异的均方根（RMSSD）和高频（HF）值显着较低，在重度吸烟者。TO与SDNN、SDANN、RMSSD、LF、高频（HF）呈显著相关，仅HF与TS呈显著相关。HRT是评价香烟对植物神经功能影响的一种无创性方法。同时异常的HRT和HRV值可以解释重度吸烟者心血管事件风险的增加。
Methods: Heavy cigarette smoking was defined as more than 20 cigarettes smoked per day. Heavy cigarette smokers, 69 subjects and nonsmokers 74 subjects (control group) were enrolled in this study. HRV and HRT analyses [turbulence onset (TO) and turbulence slope (TS)] were assessed from 24-hour Holter recordings.Results: The values of TO were significantly higher in heavy cigarette smokers than control group (-1.150 +/- 4.007 vs -2.454 +/- 2.796, P = 0.025, respectively), but values of TS were not statistically different between two groups (10.352 +/- 7.670 vs 9.613 +/- 7.245, P = 0.555, respectively). Also, the number of patients who had abnormal TO was significantly higher in heavy cigarette smokers than control group (23 vs 10, P = 0.006). TO was correlated with the number of cigarettes smoked per day (r = 0.235, P = 0.004). While LF and LF/HF ratio were significantly higher, standard deviation of all NN intervals (SDNN), standard deviation of the 5-minute mean RR intervals (SDANN), root mean square of successive differences (RMSSD), and high-frequency (HF) values were significantly lower in heavy smokers. While, there was significant correlation between TO and SDNN, SDANN, RMSSD, LF, and high frequency (HF), only HF was correlated with TS.Conclusion: Heavy cigarette smoking has negative effect on autonomic function. HRT is an appropriate noninvasive method to evaluate the effect of cigarette on autonomic function. Simultaneous abnormal HRT and HRV values may explain increased cardiovascular event risk in heavy cigarette smokers.