Circadian patterns of sleep, sleepiness, and performance in older and younger adults
Circadian patterns of sleep, sleepiness, and performance in older and younger adults
复制标题
DOI：
10.1093/sleep/28.11.1365
复制
发表时间：
2005-11-01
期刊：
影响因子：
5.6
通讯作者：
Begley, A
中科院分区：
文献类型：
--
作者：
Buysse, DJ;Monk, TH;Begley, A
研究目的：比较老年人和年轻人的睡眠昼夜节律模式、主观嗜睡和心理表现。设计：对照实验室研究地点：综合临床研究中心参与者：健康老年人（n = 17，平均年龄76岁）和健康年轻成人（n = 19，平均年龄23岁）干预：受试者在90分钟的睡眠-觉醒周期（30分钟在床上，60分钟清醒）中连续生活60小时。在卧床期间进行脑电图记录。自我评价和心理性能测试进行了60分钟清醒periods.Measurements和结果：数据进行了分析与余弦和线性混合模型。核心体温节律的幅度和相位在不同年龄组之间没有显著差异。老年人的总睡眠时间和睡眠效率的平均水平和幅度的节奏显着降低，增加平均水平和幅度的节奏在睡眠潜伏期和觉醒后入睡。年龄组主观嗜睡的平均水平没有差异，但老年人的振幅降低。老年人的整体心理表现更差，有证据表明其中一些节律的昼夜节律幅度更大。年龄组没有不同的相位位置上的任何rhythm.Conclusions：老年人有一个较低的水平和较小的昼夜变化的睡眠倾向与年轻人相比，而觉醒和psychotherapy性能的节奏往往表现出增加的昼夜变化在老年受试者。这些发现可能是由于年龄相关的皮质功能变化，稳态睡眠机制和昼夜节律调节的组合。
Study Objective: To compare circadian patterns of sleep, subjective sleepiness, and psychomotor performance in older and younger adults.Design: Controlled experimental laboratory studySetting: General Clinical Research CenterParticipants: Healthy older adults (n = 17, mean age 76 years) and healthy younger adults (n = 19, mean age 23 years)Interventions: Subjects lived for 60 consecutive hours on a 90-minute sleep-wake cycle (30 minutes in bed, 60 minutes awake). Electroencephalographic recordings were conducted during bedrest periods. Self-ratings and psychomotor performance tests were conducted during 60-minute wake periods.Measurements and Results: Data were analyzed with cosinor and linear mixed models. Amplitude and phase of the core body temperature rhythm did not significantly differ by age group. Older adults had significantly reduced mean levels and amplitude of rhythms in total sleep time and sleep efficiency and increased mean levels and amplitude of rhythms in sleep latency and wake after sleep onset. Age groups did not differ in mean level of subjective sleepiness, but older adults had reduced amplitude. Older adults had worse overall psychomotor performance, with evidence of larger circadian amplitude in some of these rhythms. Age groups did not differ on the phase position of any rhythm.Conclusions: Older adults had a lower level and smaller circadian variation of sleep propensity compared with younger adults, whereas wakefulness and psychomotor performance rhythms tended to show increased circadian variation among older subjects. These findings likely result from a combination of age-related changes in cortical function, homeostatic sleep mechanisms, and circadian regulation.