A PSYCHOPHYSIOLOGICAL STUDY IN HUMANS USING PHASIC COLONIC DISTENSION AS A NOXIOUS VISCERAL STIMULUS
A PSYCHOPHYSIOLOGICAL STUDY IN HUMANS USING PHASIC COLONIC DISTENSION AS A NOXIOUS VISCERAL STIMULUS
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DOI：
10.1016/0304-3959(90)90035-c
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发表时间：
1990-12-01
期刊：
影响因子：
7.4
通讯作者：
GEBHART, GF
中科院分区：
文献类型：
--
作者：
NESS, TJ;METCALF, AM;GEBHART, GF
用乙状结肠恒压阶段性扩张(30秒，20-70毫米汞柱)作为内脏刺激，在9人上进行了心理生理学实验。9名受试者中有8名除了有压力/痛感的报道外，还有可靠的心血管(升压)、呼吸和内脏运动反应。压力/痛感涉及下腹部、下背部和会，并使用视觉模拟标尺量化其强度。对结肠扩张的反应是分级的，并随着相同强度(60 Mm Hg)的重复扩张而增加。受试者图画所示的参照区域随着反复扩张而增加，受试者的感觉和情感描述的强度也随之增加。其中五名受试者区分了由结肠扩张引起的“压力”和“疼痛”感觉；在扩张刺激过程中，“疼痛”感觉的强度加快，而在扩张刺激过程中，“压力”感觉通常是稳定的或适应的。
Psychophysiological experiments were performed in 9 humans using constant-pressure, phasic, graded distension (30 sec, 20-70 mm Hg) of the sigmoid colon as a visceral stimulus. Reliable cardiovascular (pressor), respiratory and visceromotor responses in addition to reports of pressure/pain sensations were evoked by colonic distension in 8 of the 9 subjects. The pressure/pain sensations were referred to the lower abdomen, lower back and perineum and their intensity quantified using a visual analogue scale. Responses to colonic distension were graded and increased with repeated distensions at the same intensity (60 mm Hg). The area of referral as indicated by subject drawings increased with repeated distensions as did the intensity of the subjects' sensory and affective descriptors of the sensation. Five of the subjects differentiated between 'pressure' and 'pain' sensations evoked by colonic distension; the intensity of the 'pain' sensation accelerated during the distending stimulus whereas the 'pressure' sensation was typically stable or adapting during the distending stimulus.