Mechanisms of angiogenesis
Mechanisms of angiogenesis
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DOI：
10.1038/386671a0
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发表时间：
1997-04-17
期刊：
影响因子：
64.8
通讯作者：
Risau, W
中科院分区：
文献类型：
--
作者：
Risau, W
在发育中的胚胎通过称为血管发生的过程形成初级血管丛后，通过发芽和非发芽血管生成产生更多的血管，这些血管逐渐被修剪并重塑为功能成熟的循环系统。最近的研究结果，特别是对缺乏相关信号系统的小鼠的研究，极大地提高了我们对这些事件背后的分子基础的理解，并可能为治疗依赖血管生成的癌症等疾病提供新的方法。
After the developing embryo has formed a primary vascular plexus by a process termed vasculogenesis, further blood vessels are generated by both sprouting and non-sprouting angiogenesis, which are progressively pruned and remodelled into a functional adult circulatory system. Recent results, particularly from the study of mice lacking some of the signalling systems involved, have greatly improved our understanding of the molecular basis underlying these events, and may suggest new approaches for treating conditions such as cancer that depend on angiogenesis.