Early music exposure modifies GluR2 protein expression in rat auditory cortex and anterior cingulate cortex
Early music exposure modifies GluR2 protein expression in rat auditory cortex and anterior cingulate cortex
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早期音乐暴露改变大鼠听觉皮层和前扣带皮层 GluR2 蛋白表达
DOI：
10.1016/j.neulet.2007.05.005
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发表时间：
2007-06-13
影响因子：
2.5
通讯作者：
Sun, Xinde
中科院分区：
文献类型：
--
作者：
Xu, Feng;Cai, Rui;Sun, Xinde
GluR2是AMPA受体的主要亚基，在脑功能活动中起重要作用。我们研究了发育期间音乐暴露对SD大鼠听觉皮层（AC）和前扣带皮层（ACC） GluR2蛋白表达水平的影响。将大鼠分为三组，Music1组（播放怀旧音乐）、Music2组（播放Wishmaster）和对照组（不播放音乐）。对于音乐暴露组，大鼠从出生后第14天（PND）开始接触音乐，并在PND 28、42和56时检测GluR2蛋白的表达水平。对照组在PND1、3、5、7、9、11、14、21、28、42和56处检测GluR2蛋白的表达水平。结果显示GluR2蛋白在对照大鼠中呈年龄依赖性表达。在AC中，暴露于Music2显著增加GluR2的表达，而暴露于Music I则没有影响。在ACC中，我们发现GluR2的时间依赖性表达在音乐暴露大鼠和对照大鼠之间存在显著差异。这些结果表明，音乐暴露可以改变AC和ACC中GluR2蛋白的表达水平。2007爱思唯尔爱尔兰有限公司版权所有。
GluR2, a major subunit in AMPA receptor, plays an important role in brain functional activity. We studied the effect of music exposure during development on the expression level of GluR2 proteins in the auditory cortex (AC) and anterior cingulate cortex (ACC) of SD rats. Rats were divided into three groups, Music1 (exposed to Nostalgy) group, Music2 (exposed to Wishmaster) group, and control (no music exposure) group. For music exposure groups, rats were exposed to music from postnatal day (PND) 14, and the expression levels of GluR2 proteins were determined at PND 28, 42 and 56. For the control group, the expression levels of GluR2 proteins were determined at PND1, 3, 5, 7, 9, 11, 14, 21, 28, 42, and 56. Results showed an age-dependent expression of GluR2 proteins in control rats. In AC, exposure to Music2 dramatically increased the expression of GluR2, while exposure to Music I had no effect. In ACC, we found remarkable discrepancies in time-dependent expression of GluR2 between music exposed rats and control rats. These results indicate that exposure to music can modify the expression level of GluR2 protein in AC and ACC. (c) 2007 Elsevier Ireland Ltd. All rights reserved.