IS THE SPHERE ORGANELLE COILED BODY A UNIVERSAL NUCLEAR-COMPONENT
IS THE SPHERE ORGANELLE COILED BODY A UNIVERSAL NUCLEAR-COMPONENT
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DOI：
10.1002/dvg.1020160107
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发表时间：
1995-01-01
期刊：
影响因子：
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通讯作者：
MURPHY, C
中科院分区：
文献类型：
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作者：
GALL, JG;TSVETKOV, A;MURPHY, C
我们提出的证据的基本同源性的四个核细胞器，以前已被描述为四个不同的名称：在哺乳动物体细胞核的卷曲体，prenucleolar机构在体外组装在非洲爪蟾卵提取物，球形细胞器在两栖动物germinal囊泡（GV），和Binnenkorper在昆虫GV。这些细胞器中的每一个都含有卷曲蛋白或卷曲蛋白相关蛋白以及各种小的核核糖核蛋白。我们认为，球形细胞器/卷曲体是一个“普遍的”核组件的意义上说，它是参与共同的核过程，因此将被发现在一种形式或另一种在大多数真核细胞。我们假设它在snRNP复合物的组装和分选中起作用，用于三种RNA加工途径：前体mRNA剪接、rRNA加工和组蛋白前体mRNA 3'末端形成。具体来说，球状细胞器/卷曲体可能是加工复合物组装的初始位点，然后将其分选到细胞核中的其他位置，在那里发生实际的RNA加工。(C)1995年Wiley-Liss，Inc.
We present evidence for the essential homology of four nuclear organelles that have previously been described under four different names: coiled bodies in mammalian somatic nuclei, prenucleolar bodies in nuclei assembled in vitro in Xenopus egg extract, sphere organelles in amphibian germinal vesicles (GVs), and Binnenkorper in insect GVs. Each of these organelles contains coilin or a coilin-related protein plus a variety of small nuclear ribonucleoproteins. We suggest that the sphere organelle/coiled body is a ''universal'' nuclear component in the sense that it is involved in common nuclear processes and hence will be found in one form or another in most eukaryotic cells. We postulate that it functions in the assembly and sorting of snRNP complexes for three RNA processing pathways: pre-mRNA splicing, rRNA processing, and histone pre-mRNA 3' end formation. Specifically, the sphere organelle/coiled body may be the initial site for assembly of processing complexes, which are then sorted to other places in the nucleus, where the actual RNA processing takes place. (C) 1995 Wiley-Liss, Inc.