Pre- and perinatal complications and risk for bipolar disorder: a retrospective study.
Pre- and perinatal complications and risk for bipolar disorder: a retrospective study.
复制标题
产前和围产期并发症以及双相情感障碍的风险：一项回顾性研究。
DOI：
10.1016/s0165-0327(98)00015-9
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发表时间：
1998
影响因子：
6.6
通讯作者：
Tramer,S
中科院分区：
文献类型：
--
作者：
Kinney,DK;Yurgelun-Todd,DA;Tohen,M;Tramer,S
BackgroundMany studies have reported that obstetric complications are risk factors for schizophrenia, but few studies have examined whether complications increase risk for bipolar disorder.MethodsBipolar-disorder probands and their adult siblings were diagnosed using DSM-III-R criteria. Obstetrical data from maternal reports were scored, blind to diagnosis, applying published scales that take into account number and severity of complications.ResultsObstetric complication scores were significantly worse in probands than siblings without mood disorders.LimitationsProbands had relatively severe symptoms; research using more heterogeneous samples is needed.ConclusionResults suggest obstetric complications are etiologically significant in bipolar disorder.
