Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice.
Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice.
复制标题
早期细胞募集方面的缺陷，致使糖尿病小鼠对呼吸道肺炎克雷伯菌感染的易感性增加。
DOI：
10.1016/j.micinf.2016.05.007
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发表时间：
2016-10
影响因子：
5.8
通讯作者：
Kornfeld, Hardy
中科院分区：
文献类型：
--
作者：
Martinez, Nuria;Ketheesan, Natkunam;Martens, Gregory W.;West, Kim;Lien, Egil;Kornfeld, Hardy
糖尿病与肺炎克雷伯菌易感性增加和感染预后不良有关。我们证明了链脲佐菌素诱导的糖尿病小鼠气管滴注K。肺炎。糖尿病小鼠在气管滴注K后，肺泡气隙中的粒细胞较少，并且早期产生的CXCL1、CXCL2、IL-1 β和TNF-α减少。肺炎-脂多糖。此外，K.肺炎-脂多糖暴露在高血糖小鼠中减少。这些发现表明先天感觉受损和不能迅速将粒细胞募集到感染部位是糖尿病对呼吸道钾敏感性的一种机制。肺炎感染。
Diabetes is associated with increased susceptibility to Klebsiella pneumoniae and poor prognosis with infection. We demonstrate accelerated mortality in mice with streptozotocin-induced diabetes following tracheal instillation of K. pneumoniae. Diabetic mice recruited fewer granulocytes to the alveolar airspace and had reduced early production of CXCL1, CXCL2, IL-1β and TNF-α following tracheal instillation of K. pneumoniae-lipopolysaccharide. Additionally, TLR2 and TIRAP expression following K. pneumoniae-lipopolysaccharide exposure was decreased in hyperglycemic mice. These findings indicate that impaired innate sensing and failure to rapidly recruit granulocytes to the site of infection is a mechanism for diabetic susceptibility to respiratory K. pneumoniae infection.
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DOI：
10.4049/jimmunol.0903843
发表时间：
2010-11-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cai S;Batra S;Lira SA;Kolls JK;Jeyaseelan S
通讯作者：
Jeyaseelan S
影响因子：
5.4
作者：
Teixeira-Coelho M;Guedes J;Ferreirinha P;Howes A;Pedrosa J;Rodrigues F;Lai WS;Blackshear PJ;O'Garra A;Castro AG;Saraiva M
通讯作者：
Saraiva M
影响因子：
11.8
作者：
Boucher, Helen W.;Talbot, George H.;Bartlett, John
通讯作者：
Bartlett, John
影响因子：
11.8
作者：
Wang, JL;Chen, KY;Chang, SC
通讯作者：
Chang, SC
影响因子：
4.4
作者：
Jeyaseelan, Samithamby;Young, Scott K.;Worthen, G. Scott
通讯作者：
Worthen, G. Scott