PULMONARY GAS TRAPPING DIFFERENCES AMONG ANIMAL SPECIES IN RESPONSE TO INTRAVENOUS-INFUSION OF PERFLUOROCARBON EMULSIONS
PULMONARY GAS TRAPPING DIFFERENCES AMONG ANIMAL SPECIES IN RESPONSE TO INTRAVENOUS-INFUSION OF PERFLUOROCARBON EMULSIONS
复制标题
DOI：
10.3109/10731199409138816
复制
发表时间：
1994-01-01
影响因子：
--
通讯作者：
FLAIM, SF
中科院分区：
文献类型：
--
作者：
LEAKAKOS, T;SCHUTT, EG;FLAIM, SF
在动物中，以乳剂形式静脉注射较高蒸汽压的全氟化碳（PFC）后，可能会出现肺容量增加和尸检时肺正常塌陷的伴随故障。根据PFC、剂量和动物模型的不同，反应差异很大。研究目的是检查动物种属在这种明显的肺部气体捕获（PGT）现象方面的差异，这种现象在人体临床试验中尚未观察到。在用浓缩的全氟溴龙乳剂或Fluosol（R）处理后，观察到死后肺体积的剂量相关性增加。它在猪、兔子和猴子中最明显，在小鼠和狗中基本上不存在。在大多数物种中未观察到对动脉血气的明显影响，但在给予最高PFC剂量的猴子中，PaO2水平短暂降低。与Fluosol相比，Perflubron乳剂的肺部效应可逆性发生得更快。反映肺中PFC颗粒存在的单核细胞染色和肺泡扩张在种属间存在差异，但未观察到病变或水肿。侧支通气、气道形态和肺血管内巨噬细胞的种属差异可能影响其敏感性，并导致种属间对静脉给药PFC乳剂反应的差异。
In animals, increased lung volume and a concomitant failure of lungs to collapse normally upon autopsy can occur following intravenous injection of higher vapor pressure perfluorocarbons (PFCs) administered as emulsions. Responses vary considerably depending on the PFC, dose and animal model. The study objective was to examine animal species differences with respect to this apparent pulmonary gas trapping (PGT) phenomenon which has not been observed in human clinical trials. A dose-related increase in postmortem lung volume following treatment with either a concentrated perflubron emulsion or Fluosol(R) was observed. It was most pronounced in pigs, rabbits and monkeys, and essentially nonexistent in mice and dogs. No clear effects on arterial blood gases were seen in most species, but PaO2 levels were reduced transiently in monkeys given the highest PFC doses. Reversibility of pulmonary effects occurred more rapidly with perflubron emulsions than with Fluosol. Vacuolated mononuclear cells, reflecting the presence of PFC particles in the lung, and alveolar distention varied between species, but no lesions or edema were observed. Species differences in collateral ventilation, airway morphology and pulmonary intravascular macrophages may influence their sensitivity and contribute to the interspecies differences in response to intravenously administered PFC emulsions.